Reactome | PNPLA6 hydrolyzes LysoPtdCho

PNPLA6 hydrolyzes LysoPtdCho

Stable Identifier

R-HSA-6814254

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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PNPLA6 (Patatin-like phospholipase domain-containing protein 6, also known as NTE - Neuropathy target esterase) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The subcellular location of the enzyme and its specificity have been established through studies of recombinant human enzyme (Li et al. 2003; Zaccheo et al. 2004). Additional studies in a mouse system indicate that enzyme abundance and activity are regulated by osmotic stress in the kidney (Gallazzini et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12514188	Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells Li, Y, Dinsdale, D, Glynn, P	J. Biol. Chem.	2003
15044461	Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells Zaccheo, O, Dinsdale, D, Meacock, PA, Glynn, P	J. Biol. Chem.	2004
17015841	Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl Gallazzini, M, Ferraris, JD, Kunin, M, Morris, RG, Burg, MB	Proc. Natl. Acad. Sci. U.S.A.	2006