PNPLA6 hydrolyzes LysoPtdCho

Stable Identifier
Reaction [transition]
Homo sapiens
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PNPLA6 (Patatin-like phospholipase domain-containing protein 6, also known as NTE - Neuropathy target esterase) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The subcellular location of the enzyme and its specificity have been established through studies of recombinant human enzyme (Li et al. 2003; Zaccheo et al. 2004). Additional studies in a mouse system indicate that enzyme abundance and activity are regulated by osmotic stress in the kidney (Gallazzini et al. 2006).

Literature References
PubMed ID Title Journal Year
12514188 Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells

Li, Y, Dinsdale, D, Glynn, P

J. Biol. Chem. 2003
15044461 Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells

Meacock, PA, Dinsdale, D, Zaccheo, O, Glynn, P

J. Biol. Chem. 2004
17015841 Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl

Kunin, M, Morris, RG, Ferraris, JD, Burg, MB, Gallazzini, M

Proc. Natl. Acad. Sci. U.S.A. 2006
Catalyst Activity

lysophospholipase activity of PNPLA6 [endoplasmic reticulum membrane]

Orthologous Events
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