PNPLA6 hydrolyzes LysoPtdCho

Stable Identifier
R-HSA-6814254
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PNPLA6 (Patatin-like phospholipase domain-containing protein 6, also known as NTE - Neuropathy target esterase) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The subcellular location of the enzyme and its specificity have been established through studies of recombinant human enzyme (Li et al. 2003; Zaccheo et al. 2004). Additional studies in a mouse system indicate that enzyme abundance and activity are regulated by osmotic stress in the kidney (Gallazzini et al. 2006).

Literature References
PubMed ID Title Journal Year
15044461 Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells

Zaccheo, O, Dinsdale, D, Meacock, PA, Glynn, P

J. Biol. Chem. 2004
12514188 Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells

Li, Y, Dinsdale, D, Glynn, P

J. Biol. Chem. 2003
17015841 Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl

Gallazzini, M, Ferraris, JD, Kunin, M, Morris, RG, Burg, MB

Proc. Natl. Acad. Sci. U.S.A. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysophospholipase activity of PNPLA6 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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