GDE1 (glycerophosphodiester phosphodiesterase 1) catalyzes the hydrolysis of GroPIns (1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol; glycerophosphoinositol) to G3P (glycerol-3-phosphate) and Ins (inositol). Experimental studies of the homologous rat enzyme have shown it to be associated with cellular membranes, to have a strong preference for glycerophosphoinositol over glycerophosphocholine as a substrate, and to be stimulated by G protein agonists, suggesting a possible role for GDE1 in signaling by G protein-coupled receptors (Zheng et al. 2000, 2003). Modeling studies with the human protein have been interpreted to suggest localization specifically to the plasma membrane (Bachmann et al. 2006).
Bachmann, AS, Duennebier, FF, Mocz, G
Zheng, B, Berrie, CP, Corda, D, Farquhar, MG
Zheng, B, Chen, D, Farquhar, MG
glycerophosphoinositol glycerophosphodiesterase activity of GDE1 [plasma membrane]
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