Reactome | ANAPC15 [nucleoplasm]

ANAPC15 [nucleoplasm]

Stable Identifier

R-BTA-6805136

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

ANAPC15, Q3SZ31

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle, Mitotic (Bos taurus)
  - Regulation of mitotic cell cycle (Bos taurus)
    - APC/C-mediated degradation of cell cycle proteins (Bos taurus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Bos taurus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
        
        Phosphorylation of the APC/C (Bos taurus)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Free APC/C phosphorylated by Plk1 (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Bos taurus)
        
        Degradation of multiubiquitinated Cdh1 (Bos taurus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Bos taurus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Multiubiquitination of APC/C-associated Cdh1 (Bos taurus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Bos taurus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
      - Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Bos taurus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)

Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular Senescence (Bos taurus)
    - Senescence-Associated Secretory Phenotype (SASP) (Bos taurus)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Bos taurus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Bos taurus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Bos taurus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)
        
        ANAPC15 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q3SZ31

Gene Names

ANAPC15

Reference Genes

BioGPS Gene:101905242 ANAPC15

BioGPS Gene:505356 ANAPC15

ENSEMBL:ENSBTAG00000002999

ENSEMBL:ENSBTAG00000002999.5 ANAPC15

KEGG Gene (Bos taurus):101905242 ANAPC15

KEGG Gene (Bos taurus):505356 ANAPC15

Monarch:101905242 ANAPC15

Monarch:505356 ANAPC15

NCBI Gene:101905242 ANAPC15

NCBI Gene:505356 ANAPC15

Reference Transcript

Other Identifiers

505356

GO:0000278

GO:0005634

GO:0005680

GO:0007049

GO:0007059

GO:0023052

GO:0043226

GO:0051301

GO:0090266

GO:0140014

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Bos taurus)

Other forms of this molecule

ANAPC15 [cytosol]

Inferred From

ANAPC15 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_010822824.1, NP_001029415.1, XP_010799290.1

OpenTargets

ENSG00000110200

Ensembl

ENSBTAG00000002999, ENSBTAP00000003902, ENSBTAT00000003902

VGNC

25882

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