Reactome | HSPA1A [nucleoplasm]

HSPA1A [nucleoplasm]

Stable Identifier

R-HSA-6792605

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HSP70, heat shock 70kDa protein 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Export of Viral Ribonucleoproteins from Nucleus (Homo sapiens)
        
        Viral RNP Complexes in the Host Cell Nucleus (Homo sapiens)
        
        Binding of M1 to vRNP (Homo sapiens)
        
        HSPA1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0DMV8 HSPA1A

Gene Names

HSPA1A, HSPA1, HSX70, HSP72

Chain

initiator methionine:1, chain:2-641

Reference Genes

BioGPS Gene:3303 HSPA1A

BioGPS Gene:3304 HSPA1A

COSMIC (genes):HSPA1A HSPA1A

CTD Gene:3303 HSPA1A

CTD Gene:3304 HSPA1A

dbSNP Gene:3303 HSPA1A

dbSNP Gene:3304 HSPA1A

ENSEMBL:ENSG00000204389 HSPA1A

ENSEMBL:ENSG00000204389.10 HSPA1A

ENSEMBL:ENSG00000215328 HSPA1A

ENSEMBL:ENSG00000215328.6 HSPA1A

ENSEMBL:ENSG00000234475 HSPA1A

ENSEMBL:ENSG00000234475.5 HSPA1A

ENSEMBL:ENSG00000235941 HSPA1A

ENSEMBL:ENSG00000235941.5 HSPA1A

ENSEMBL:ENSG00000237724 HSPA1A

ENSEMBL:ENSG00000237724.5 HSPA1A

HGNC:5232 HSPA1A

KEGG Gene (Homo sapiens):3303 HSPA1A

KEGG Gene (Homo sapiens):3304 HSPA1A

Monarch:3303 HSPA1A

Monarch:3304 HSPA1A

NCBI Gene:3303 HSPA1A

NCBI Gene:3304 HSPA1A

OMIM:140550 HSPA1A

OMIM:603012 HSPA1A

Reference Transcript

Other Identifiers

1104_s_at

11744413_x_at

11757907_x_at

17006863

17006881

17026318

17026331

17027994

17028007

17030820

17030833

17038297

17038309

200799_PM_at

200799_at

200800_PM_s_at

200800_s_at

2902708

2902709

2902710

2902711

2902712

2902713

2902714

2902715

2902716

2902728

2902729

31692_at

3303

8118310

8118314

8178086

8179322

8179324

A_14_P121486

A_14_P200184

A_23_P111132

A_24_P123616

A_24_P682285

GE81493

GO:0000122

GO:0000166

GO:0000278

GO:0001618

GO:0001664

GO:0002376

GO:0003714

GO:0003723

GO:0003824

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005783

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005925

GO:0006351

GO:0006355

GO:0006402

GO:0006457

GO:0006986

GO:0007005

GO:0007010

GO:0007041

GO:0007165

GO:0008180

GO:0008285

GO:0010628

GO:0012501

GO:0016071

GO:0016234

GO:0016235

GO:0016607

GO:0016787

GO:0016887

GO:0019899

GO:0023052

GO:0030154

GO:0030163

GO:0030308

GO:0030512

GO:0031072

GO:0031249

GO:0031396

GO:0031397

GO:0031410

GO:0031625

GO:0031982

GO:0032436

GO:0032757

GO:0032991

GO:0033120

GO:0034599

GO:0034605

GO:0034620

GO:0036211

GO:0038177

GO:0042026

GO:0042826

GO:0043066

GO:0043226

GO:0044183

GO:0045296

GO:0045648

GO:0046034

GO:0046718

GO:0048018

GO:0048471

GO:0048856

GO:0050821

GO:0051082

GO:0051085

GO:0051092

GO:0051131

GO:0051787

GO:0055086

GO:0055131

GO:0061024

GO:0065003

GO:0070062

GO:0070370

GO:0070434

GO:0071383

GO:0072562

GO:0090063

GO:0090084

GO:0097718

GO:0098772

GO:0140014

GO:0140110

GO:0140416

GO:0140545

GO:0140657

GO:0140662

GO:1901029

GO:1901135

GO:1901673

GO:1902236

GO:1902380

GO:1903265

GO:1904813

GO:1990904

GO:2001240

HMNXSV003042623

ILMN_1789074

M11717_rna1_at

PH_hs_0028967

PH_hs_0031321

TC06000384.hg

TC06000385.hg

TC6_apd_hap1000039.hg

TC6_cox_hap2000078.hg

TC6_dbb_hap3000069.hg

TC6_qbl_hap6000069.hg

g5579469_3p_at

Participates

as a component of

as a member of

This entity regulates

Negatively

Binding of M1 to vRNP (Homo sapiens)

Other forms of this molecule

HSPA1A [cytosol]

HSPA1A [extracellular region]

HSPA1A [ficolin-1-rich granule lumen]

Inferred To

Hsp70Ab [nucleoplasm] (Drosophila melanogaster)

hsp70 [nucleoplasm] (Danio rerio)

Homologues of HSPA1A [nucleoplasm] (Danio rerio)

Homologues of HSPA1A [nucleoplasm] (Drosophila melanogaster)

Homologues of HSPA1A [nucleoplasm] (Mus musculus)

Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)

Homologues of HSPA1A [nucleoplasm] (Sus scrofa)

Hsp70Bb [nucleoplasm] (Drosophila melanogaster)

Hsp68 [nucleoplasm] (Drosophila melanogaster)

Hsp70Aa [nucleoplasm] (Drosophila melanogaster)

Hsc70-2 [nucleoplasm] (Drosophila melanogaster)

Hsp70Ba [nucleoplasm] (Drosophila melanogaster)

hsp70.1 [nucleoplasm] (Danio rerio)

Hsp70Bbb [nucleoplasm] (Drosophila melanogaster)

Hsp70Bc [nucleoplasm] (Drosophila melanogaster)

HSPA1A [nucleoplasm] (Bos taurus)

HSPA1A [nucleoplasm] (Caenorhabditis elegans)

HSPA1A [nucleoplasm] (Canis familiaris)

HSPA1A [nucleoplasm] (Danio rerio)

HSPA1A [nucleoplasm] (Mus musculus)

HSPA1A [nucleoplasm] (Rattus norvegicus)

HSPA1A [nucleoplasm] (Sus scrofa)

HSPA1A [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005336.3, NP_005337.2

Guide to Pharmacology - Targets

2539

OpenTargets

ENSG00000204389

GeneCards

P0DMV8

HPA

ENSG00000204389-HSPA1A

Ensembl

ENSG00000215328, ENSG00000235941, ENSP00000406359, ENSP00000404524, ENSG00000237724, ENST00000375651, ENSG00000234475, ENST00000433487, ENSP00000364802, ENSG00000204389, ENST00000400040, ENST00000441618, ENST00000430065, ENSP00000382915, ENSP00000408907

PRO

P0DMV8

Pharos - Targets

P0DMV8

Orphanet

24606

HMDB Protein

HMDBP14535

PDB

3ATU, 4PO2, 6G3S, 2E88, 4J8F, 2LMG, 5BN9, 5XIR, 4WV7, 3D2F, 5BN8, 7FGM, 5GJJ, 6JPV, 3JXU, 3D2E, 5MKS, 4WV5, 4IO8, 1S3X, 5MKR, 5BPN, 5AQZ, 1HJO, 2E8A, 3A8Y, 7Q4R, 5XI9, 5AR0, 1XQS, 5BPM, 5AQY, 5BPL, 6ZYI, 5AQX, 3ATV, 3Q49, 6K39, 3AY9, 6FHK, 3LOF, 7KW7, 5AQW, 6G3R

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60260-5 PRKN			0.556	6
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P43405-2 P434052			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.556	3
UniProt:O75832 PSMD10	2	PSMD10 [cytosol] (R-HSA-68788) PSMD10 [nucleoplasm] (R-HSA-174322)	0.544	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.527	2
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.508	2