Reactome | HSPA1A [nucleoplasm]

HSPA1A [nucleoplasm]

Stable Identifier

R-MMU-6792605

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

P17879

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to heat stress (Mus musculus)
    - HSF1-dependent transactivation (Mus musculus)
      - Attenuation phase (Mus musculus)
        
        HSF1 acetylation at Lys80 (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 binds HSF1 (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
      - HSF1-mediated gene expression (Mus musculus)
        
        Heat shock inducible proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
    - Regulation of HSF1-mediated heat shock response (Mus musculus)
      - HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)
        
        HSP70s:ADP [nucleoplasm] (Mus musculus)
        
        HSPA1A:ADP [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSPA1A:ATP [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
      - NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSPA1A:ATP [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
      - SIRT1 binds to HSF1 (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
      - SIRT1 deacetylates HSF1 (Mus musculus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        HSPA1A [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P17879

Reference Genes

ENSEMBL:ENSMUSG00000090877

UCSC:P17879

Other Identifiers

100946_at

10450367

1427126_at

1427127_x_at

1452318_a_at

15511

17344126

5337357

A_52_P304902

A_52_P52803

A_55_P2068459

GO:0000166

GO:0002199

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006457

GO:0007339

GO:0009408

GO:0016787

GO:0016887

GO:0031072

GO:0032436

GO:0042026

GO:0043066

GO:0044183

GO:0044297

GO:0090063

GO:0140662

GO:1901673

ILMN_2498263

ILMN_2530672

mMC015201

Participates

as a member of

Homologues of HSPA1A [nucleoplasm] (Mus musculus)

Other forms of this molecule

HSPA1A [extracellular region]

HSPA1A [ficolin-1-rich granule lumen]

HSPA1A [cytosol]

Inferred From

HSPA1B [nucleoplasm] (Homo sapiens)

HSPA1A [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSG00000090877, ENSMUST00000172753, ENSMUSP00000133815

PRO

P17879

MGI

99517

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P70196 Traf6	1	Traf6 [cytosol] (R-MMU-933459)	0.524	3
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2

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