Reactome | GTPBP3 [mitochondrial matrix]

GTPBP3 [mitochondrial matrix]

Stable Identifier

R-HSA-6787414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

tRNA modification GTPase GTPBP3, mitochondrial, GTPB3_HUMAN

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External Reference Information

External Reference

UniProt:Q969Y2 GTPBP3

Gene Names

GTPBP3, MTGP1

Chain

transit peptide:1-81, chain:82-492

Reference Genes

BioGPS Gene:84705 GTPBP3

COSMIC (genes):GTPBP3 GTPBP3

CTD Gene:84705 GTPBP3

dbSNP Gene:84705 GTPBP3

ENSEMBL:ENSG00000130299 GTPBP3

ENSEMBL:ENSG00000130299.17 GTPBP3

HGNC:14880 GTPBP3

KEGG Gene (Homo sapiens):84705 GTPBP3

Monarch:84705 GTPBP3

NCBI Gene:84705 GTPBP3

OMIM:608536 GTPBP3

UCSC:Q969Y2 GTPBP3

Reference Transcript

Other Identifiers

11724991_a_at

11724992_x_at

11733958_a_at

11733959_x_at

11753176_a_at

1555062_PM_s_at

1555062_s_at

16859493

213835_PM_x_at

213835_x_at

3824227

3824232

3824233

3824234

3824240

3824242

3824243

3824244

3824247

3824248

3824249

3824250

3824251

3824253

3824254

3824255

3824256

3824257

3824258

8026735

84705

A_23_P28068

GE83456

GO:0000166

GO:0002098

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005739

GO:0006399

GO:0006400

GO:0008033

GO:0016787

GO:0030488

GO:0043226

HMNXSV003043297

Hs.246112.3.S1_3p_at

Hs2.334885.3.S1_3p_s_at

ILMN_1686587

ILMN_1748894

ILMN_1777156

PH_hs_0016491

TC19000333.hg

This entity regulates

Positively

GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)

Cross References

RefSeq

NP_001182351.1, NP_116009.2, NP_598399.2, NP_001122327.1

OpenTargets

ENSG00000130299

GeneCards

Q969Y2

HPA

ENSG00000130299-GTPBP3

Ensembl

ENSP00000351644, ENSP00000473150, ENST00000358792, ENSP00000354598, ENSG00000130299, ENST00000324894, ENSP00000313818, ENST00000361619, ENST00000600625

PRO

Q969Y2

Pharos - Targets

Q969Y2

Orphanet

23588

HMDB Protein

HMDBP08440

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N7W2-2 BEND7			0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:Q9UC07-2 ZNF69			0.556	3
UniProt:Q8WUT1 Q8WUT1			0.556	3
UniProt:P20807-4 CAPN3			0.556	3
UniProt:P17858 PFKL	4	PFKL [secretory granule lumen] (R-HSA-6800876) PFKL [extracellular region] (R-HSA-6806471) PFKL [ficolin-1-rich granule lumen] (R-HSA-6801030) PFKL [cytosol] (R-HSA-70459)	0.556	3
UniProt:Q96D03 DDT4L			0.556	5
UniProt:Q9NR21-1 PARP11			0.556	7
UniProt:Q9Y223 GNE	9	GNE V572L [cytosol] (R-HSA-4088323) GNE M712T [cytosol] (R-HSA-4088386) GNE R263L [cytosol] (R-HSA-4088402) GNE R266W [cytosol] (R-HSA-4088372) GNE R266Q [cytosol] (R-HSA-4088390) GNE A631V [cytosol] (R-HSA-4088376) GNE M171V [cytosol] (R-HSA-4088351) GNE C303V [cytosol] (R-HSA-4088366) GNE [cytosol] (R-HSA-3781927)	0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.556	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.556	3
UniProt:Q15293 RCN1	2	p-RCN1 [endoplasmic reticulum lumen] (R-HSA-8956989) RCN1 [endoplasmic reticulum lumen] (R-HSA-8956758)	0.556	3
UniProt:Q6DHY5 TBC3G			0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:Q53GL6 Q53GL6			0.556	5
UniProt:Q9BV29 CCD32			0.556	3
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.556	3
UniProt:Q99081-3 TCF12			0.556	3
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.553	2

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