Reactome | SET [nucleoplasm]

SET [nucleoplasm]

Stable Identifier

R-HSA-451201

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein SET, SET_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q01105 SET

Gene Names

SET

Chain

initiator methionine:1, chain:2-290

Reference Genes

BioGPS Gene:6418 SET

COSMIC (genes):SET SET

CTD Gene:6418 SET

dbSNP Gene:6418 SET

ENSEMBL:ENSG00000119335 SET

HGNC:10760 SET

KEGG Gene (Homo sapiens):6418 SET

Monarch:6418 SET

NCBI Gene:6418 SET

OMIM:600960 SET

UCSC:Q01105 SET

Reference Transcript

Other Identifiers

0001340053

11715769_a_at

11715770_x_at

11733095_s_at

200630_x_at

200631_3p_s_at

200631_s_at

210231_x_at

213047_x_at

215780_3p_s_at

215780_s_at

2648928

3190660

3190661

3190663

3190664

3190665

3190668

3190670

3190672

3190675

3190677

3190678

3190679

3190680

3190681

3190682

3535474

3764458

3988214

40189_at

6418

7917674

8158372

A_23_P217015

GO:0003674

GO:0003677

GO:0003682

GO:0004864

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005811

GO:0005829

GO:0006260

GO:0006334

GO:0006337

GO:0006464

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0016032

GO:0019888

GO:0022607

GO:0030234

GO:0032515

GO:0032991

GO:0034641

GO:0034655

GO:0035067

GO:0042393

GO:0043226

GO:0043488

GO:0043524

GO:0043666

GO:0044403

GO:0045892

GO:0048471

GO:0051276

GO:0065003

HMNXSV003020731

Hs.145279.2.S1_3p_s_at

Hs.248054.0.S1_3p_s_at

ILMN_1742238

M93651_at

PH_hs_0030245

TC05003156.hg

TC09000696.hg

TC09000697.hg

X75091_s_at

g4506890_3p_a_at

g4506890_3p_s_at

g971271_3p_s_at

Participates

as a component of

as an input of

Inferred To

Homologues of SET [nucleoplasm] (Bos taurus)

Set [nucleoplasm] (Drosophila melanogaster)

Set [nucleoplasm] (Mus musculus)

Set [nucleoplasm] (Rattus norvegicus)

LOC782688 [nucleoplasm] (Bos taurus)

setb [nucleoplasm] (Danio rerio)

SET [nucleoplasm] (Bos taurus)

SET [nucleoplasm] (Canis familiaris)

SET [nucleoplasm] (Gallus gallus)

SET [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001234929.1, NP_001116293.1, NP_003002.2, NP_001234930.1

Target Pathogen

5b354852be737e166372eb70

OpenTargets

ENSG00000119335

GeneCards

Q01105

HPA

ENSG00000119335-SET

Ensembl

ENST00000372692, ENSG00000119335, ENST00000409104, ENSP00000361771, ENSP00000361777, ENSP00000318012, ENST00000372686, ENSP00000387321, ENST00000322030

PRO

Q01105

Orphanet

25729

HMDB Protein

HMDBP07996

PDB

2E50

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BT49 THAP7			0.809	7
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.684	8
UniProt:P17480 UBTF	2	UBTF [nucleoplasm] (R-HSA-73683) p-UBTF [nucleoplasm] (R-HSA-76039)	0.639	4
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.632	4
UniProt:Q15572 TAF1C	1	TAF1C [nucleoplasm] (R-HSA-73687)	0.632	4
UniProt:Q12778 FOXO1	5	p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S215 FOXO1 [nucleoplasm] (R-HSA-5692651)	0.591	5
UniProt:Q7TSY8	1	Sgo2 [cytosol] (R-MMU-376242)	0.564	3
UniProt:Q6SJ93 F111B			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P10126	6	Eef1a1 [cytosol] (R-MMU-8932419) Eef1a1 [cytosol] (R-MMU-8932212) Eef1a1 [ficolin-1-rich granule lumen] (R-MMU-6801528) Eef1a1 [extracellular region] (R-MMU-6806456) Eef1a1 [secretory granule lumen] (R-MMU-6801479) Eef1a1 [cytosol] (R-MMU-156905)	0.527	2
UniProt:P10644 PRKAR1A	2	PRKAR1A [cytosol] (R-HSA-57836) PRKAR1A [ciliary base] (R-HSA-5610408)	0.524	2
UniProt:Q53T94 TAF1B	2	Ac-TAF1B [nucleoplasm] (R-HSA-5138530) TAF1B [nucleoplasm] (R-HSA-73691)	0.524	3
UniProt:Q15573 TAF1A	1	TAF1A [nucleoplasm] (R-HSA-73689)	0.524	2
UniProt:P06454 PTMA			0.508	3

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