Reactome | SET [nucleoplasm]

SET [nucleoplasm]

Stable Identifier

R-HSA-451201

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein SET, SET_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q01105 SET

Gene Names

SET

Chain

initiator methionine:1, chain:2-290

Reference Genes

BioGPS Gene:6418 SET

COSMIC (genes):SET SET

CTD Gene:6418 SET

dbSNP Gene:6418 SET

ENSEMBL:ENSG00000119335 SET

ENSEMBL_homo_sapiens_GENE:ENSG00000119335 SET

HGNC:10760 SET

KEGG Gene (Homo sapiens):6418 SET

Monarch:6418 SET

NCBI Gene:6418 SET

OMIM:600960 SET

UCSC:Q01105 SET

Reference Transcript

Other Identifiers

0001340053

11715769_a_at

11715770_x_at

11733095_s_at

200630_x_at

200631_3p_s_at

200631_s_at

210231_x_at

213047_x_at

215780_3p_s_at

215780_s_at

2648928

2E50

3190660

3190661

3190663

3190664

3190665

3190668

3190670

3190672

3190675

3190677

3190678

3190679

3190680

3190681

3190682

3535474

3764458

3988214

40189_at

5232

63683

6418

7917674

8102309

8158372

A0A024R895

A0A0C4DFV9

A_23_P217015

AAA60318

AAC50460

AAH32749

AAQ79833

ABP96841

AEO27880

AK223556

AK300609

AK300794

AL356481

AL359678

AY349172

B2REB7

BAA08139

BAD97276

BAG62304

BAG62453

BC032749

CAA52982

CAB005232

CAG38780

CAG46847

CCDS48037

CCDS59149

CCDS6907

CH471090

CR536543

CR542050

D45198

EAW87818

EAW87819

EAW87821

EAW87822

EAW87823

EF534308

ENSG00000119335

ENSP00000318012

ENSP00000361771

ENSP00000361777

ENSP00000387321

ENST00000322030

ENST00000372686

ENST00000372692

ENST00000409104

EntrezGene:6418

g4506890_3p_a_at

g4506890_3p_s_at

g971271_3p_s_at

GO:0003674

GO:0003677

GO:0004864

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005811

GO:0005829

GO:0006259

GO:0006260

GO:0006334

GO:0006337

GO:0006464

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0016032

GO:0019888

GO:0022607

GO:0030234

GO:0032515

GO:0032991

GO:0034641

GO:0034655

GO:0035067

GO:0042393

GO:0043226

GO:0043488

GO:0043524

GO:0043666

GO:0044403

GO:0045892

GO:0048471

GO:0051276

GO:0065003

HGNC:10760

HPA063683

Hs.145279.2.S1_3p_s_at

Hs.248054.0.S1_3p_s_at

ILMN_1742238

IPR002164

IPR037231

JF729356

M93651

M93651_at

MIM:600960

MIM:618106

NM_001122821

NM_001248000

NM_003011

NP_001116293

NP_001234929

NP_003002

PF00956

PH_hs_0030245

Q5VXV3

SET

SET-201

SET-202

SET-204

SET-205

TC05003156.hg

TC09000696.hg

TC09000697.hg

U51924

uc004bvt.5

uc004bvu.5

uc022bol.2

uc064wgf.1

UPI000000162B

UPI000006D7FF

UPI000173DCFA

UPI000173DCFB

X75091

X75091_s_at

XM_017015013

XM_017015014

XM_017015015

XM_017015016

XM_024447650

XP_016870502

XP_016870503

XP_016870504

XP_016870505

XP_024303418

Participant Of

hasComponent

input

Inferred To

SET [nucleoplasm] (Bos taurus)

SET [nucleoplasm] (Canis familiaris)

SET [nucleoplasm] (Danio rerio)

SET [nucleoplasm] (Drosophila melanogaster)

SET [nucleoplasm] (Gallus gallus)

SET [nucleoplasm] (Mus musculus)

SET [nucleoplasm] (Rattus norvegicus)

SET [nucleoplasm] (Sus scrofa)

SET [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001116293.1, NP_003002.2, NP_001234930.1, NP_001234929.1

OpenTargets

ENSG00000119335

GeneCards

Q01105

DOCK Blaster

2E50

PRO

Q01105

Orphanet

25729

HMDB Protein

HMDBP07996

PDB

2E50

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BT49 THAP7			0.754	6
UniProt:P63000 RAC1	6	RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.684	8
UniProt:P17480 UBTF	2	UBTF [nucleoplasm] (R-HSA-73683) p-UBTF [nucleoplasm] (R-HSA-76039)	0.639	4
UniProt:Q15572 TAF1C	1	TAF1C [nucleoplasm] (R-HSA-73687)	0.632	4
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.632	4
UniProt:Q12778 FOXO1	5	p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S215 FOXO1 [nucleoplasm] (R-HSA-5692651)	0.591	5
UniProt:Q7TSY8	1	SGOL2 [cytosol] (R-MMU-376242)	0.564	3
UniProt:Q6SJ93 F111B			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.556	3
UniProt:P10126	6	Me3K318-EEF1A1 [cytosol] (R-MMU-8932419) Me3K79-EEF1A1 [cytosol] (R-MMU-8932212) EEF1A1 [cytosol] (R-MMU-156905) EEF1A1 [ficolin-1-rich granule lumen] (R-MMU-6801528) EEF1A1 [extracellular region] (R-MMU-6806456) EEF1A1 [secretory granule lumen] (R-MMU-6801479)	0.527	2
UniProt:P10644 PRKAR1A	2	PRKAR1A [cytosol] (R-HSA-57836) PRKAR1A [ciliary base] (R-HSA-5610408)	0.524	2
UniProt:Q53T94 TAF1B	2	Ac-TAF1B [nucleoplasm] (R-HSA-5138530) TAF1B [nucleoplasm] (R-HSA-73691)	0.524	3
UniProt:Q15573 TAF1A	1	TAF1A [nucleoplasm] (R-HSA-73689)	0.524	2
UniProt:P06454 PTMA			0.508	3