MITF-M-dependent ITGA2 gene expression

Stable Identifier
R-HSA-9926533
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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MITF-M-dependent ITGA2 gene expression
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ITGA2 encodes integrin alpha-2, an integrin receptor that dimerizes with ITGB1 (integrin beta-1) to bind laminin, collagen, fibronectin and E-cadherin in the extracellular matrix (Emsley et al, 2000; Emsley et al, 2004; Tiger et al, 2001; reviewed in Campbell and Humphries, 2011; Pang et al, 2023). MITF-M binds to the ITGA2 gene to repress its expression in melanoma cells as assessed by MITF-M knockdown, ChIP-seq, microarray and CUT-and-RUN analysis (Dilshat et al, 2021; Webster et al, 2014; Laurette et al, 2015).
MITF-M represses the expression of genes involved in extracellular matrix organization, focal adhesions and epithelial-to-mesenchymal transitions to impact the invasive/proliferative phenotype of the cell. Low levels of MITF-M are associated with a quiescent/invasive phenotype, while higher levels of MITF-M support proliferative growth (Dilshat et al, 2021; Carreira et al, 2006; Hoek et al, 2008; reviewed in Rambow et al, 2019).
Literature References
PubMed ID Title Journal Year
17182868 Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Carreira, S, Goodall, J, Denat, L, Rodriguez, M, Nuciforo, P, Hoek, KS, Testori, A, Larue, L, Goding, CR

Genes Dev 2006
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
19067971 Novel MITF targets identified using a two-step DNA microarray strategy

Hoek, KS, Schlegel, NC, Eichhoff, OM, Widmer, DS, Praetorius, C, Einarsson, SO, Valgeirsdottir, S, Bergsteinsdóttir, K, Schepsky, A, Dummer, R, Steingrímsson, E

Pigment Cell Melanoma Res 2008
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
11518510 alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells

Tiger, CF, Fougerousse, F, Grundstrom, G, Velling, T, Gullberg, D

Dev Biol 2001
10778855 Structural basis of collagen recognition by integrin alpha2beta1

Emsley, J, Knight, CG, Farndale, RW, Barnes, MJ, Liddington, RC

Cell 2000
24443471 Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

Webster, DE, Barajas, B, Bussat, RT, Yan, KJ, Neela, PH, Flockhart, RJ, Kovalski, J, Zehnder, A, Khavari, PA

Genome Res 2014
21421922 Integrin structure, activation, and interactions

Campbell, ID, Humphries, MJ

Cold Spring Harb Perspect Biol 2011
36588107 Targeting integrin pathways: mechanisms and advances in therapy

Pang, X, He, X, Qiu, Z, Zhang, H, Xie, R, Liu, Z, Gu, Y, Zhao, N, Xiang, Q, Cui, Y

Signal Transduct Target Ther 2023
31575676 Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

Rambow, F, Marine, JC, Goding, CR

Genes Dev 2019
14698296 Structure of the integrin alpha2beta1-binding collagen peptide

Emsley, J, Knight, CG, Farndale, RW, Barnes, MJ

J Mol Biol 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MITF-M dimer:ITGA2 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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