Reactome | Areg [ER to Golgi transport vesicle membrane]

Areg [ER to Golgi transport vesicle membrane]

Stable Identifier

R-MMU-5689771

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

ER to Golgi transport vesicle membrane

Synonyms

AREG precursor, P31955

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPII-mediated vesicle transport (Mus musculus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPII-mediated vesicle transport (Mus musculus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
      - COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
      - CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
      - Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)
      - Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Areg [ER to Golgi transport vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P31955

Gene Names

Areg

Reference Genes

BioGPS Gene:11839 Areg

ENSEMBL:ENSMUSG00000029378

KEGG:mmu:11839 Areg

Monarch:11839 Areg

NCBI Gene:11839 Areg

UCSC:P31955 Areg

Reference Transcript

RefSeq:NM_009704.4 Areg

Other Identifiers

10523182

11839

1421134_at

17439029

4557546

4596856

4664996

4773390

4868212

4955654

5135063

5336974

5367168

5582980

99915_at

A_52_P482897

GE35085

GO:0005125

GO:0005154

GO:0005615

GO:0005634

GO:0005737

GO:0007173

GO:0007186

GO:0008083

GO:0008284

GO:0009986

GO:0014009

GO:0014070

GO:0016020

GO:0030297

GO:0031175

GO:0032355

GO:0038127

GO:0038134

GO:0042327

GO:0042542

GO:0043226

GO:0043434

GO:0045668

GO:0048018

GO:0048856

GO:0050731

GO:0051384

GO:0051591

GO:0060598

GO:0060744

GO:0060749

GO:0060750

GO:0098772

ILMN_1238547

Msa.43.0_at

mMC006792

Participates

as a member of

TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)

Other forms of this molecule

Areg [clathrin-coated endocytic vesicle membrane]

Areg [endoplasmic reticulum-Golgi intermediate compartment membrane]

Areg [endoplasmic reticulum membrane]

Areg [extracellular region]

Inferred From

AREG precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_033834.1

ENSEMBL

ENSMUST00000031325, ENSMUSP00000031325

PRO

P31955

GlyGen

P31955

MGI

88068

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