Reactome | PIDD1 associates with CRADD

PIDD1 associates with CRADD

Stable Identifier

R-HSA-6800794

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        PIDD1 associates with CRADD (Homo sapiens)

General

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PIDD1 phosphorylated by ATM at threonine residue T788 associates with CRADD (RAIDD), forming a multisubunit structure known as the PIDDosome (Tinel and Tschopp 2004, Ando et al. 2012). The PIDDosome consists of 5 molecules of PIDD1 and 5-7 molecules of CRADD (Nematollahi et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
15073321	The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress Tinel, A, Tschopp, J	Science	2004
22854598	PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling Sanda, T, Liu, PH, Wang, J, Look, AT, Logette, E, Bouchier-Hayes, L, Kernan, JL, Tschopp, J, Ando, K, Sidi, S	Mol. Cell	2012
25528640	Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry Morgner, N, Nematollahi, LA, Garza-Garcia, A, Robinson, CV, Driscoll, PC, Bechara, C, Esposito, D	J. Mol. Biol.	2015