PIDD1 associates with CRADD

Stable Identifier
Reaction [binding]
Homo sapiens
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PIDD1 phosphorylated by ATM at threonine residue T788 associates with CRADD (RAIDD), forming a multisubunit structure known as the PIDDosome (Tinel and Tschopp 2004, Ando et al. 2012). The PIDDosome consists of 5 molecules of PIDD1 and 5-7 molecules of CRADD (Nematollahi et al. 2015).

Literature References
PubMed ID Title Journal Year
15073321 The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

Tinel, A, Tschopp, J

Science 2004
22854598 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Sanda, T, Liu, PH, Wang, J, Look, AT, Logette, E, Bouchier-Hayes, L, Kernan, JL, Tschopp, J, Ando, K, Sidi, S

Mol. Cell 2012
25528640 Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry

Morgner, N, Nematollahi, LA, Garza-Garcia, A, Robinson, CV, Driscoll, PC, Bechara, C, Esposito, D

J. Mol. Biol. 2015
Orthologous Events
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