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PPP1R15A [cytosol]
Stable Identifier
R-HSA-178231
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GADD34, GADD34-PP1c phosphatase regulatory subunit
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Translation of PPP1R15A (Homo sapiens)
PPP1R15A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PPP1R15A [cytosol] (Homo sapiens)
PPP1R15A [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PPP1R15A [cytosol] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PPP1R15A [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PPP1R15A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75807 PPP1R15A
Gene Names
PPP1R15A, GADD34
Chain
chain:1-674
Reference Genes
BioGPS Gene:23645 PPP1R15A
COSMIC (genes):PPP1R15A PPP1R15A
CTD Gene:23645 PPP1R15A
dbSNP Gene:23645 PPP1R15A
ENSEMBL:ENSG00000087074 PPP1R15A
ENSEMBL_homo_sapiens_GENE:ENSG00000087074.9 PPP1R15A
HGNC:14375 PPP1R15A
KEGG Gene (Homo sapiens):23645 PPP1R15A
Monarch:23645 PPP1R15A
NCBI Gene:23645 PPP1R15A
OMIM:611048 PPP1R15A
UCSC:O75807 PPP1R15A
Reference Transcript
RefSeq:NM_014330.3 PPP1R15A
Other Identifiers
11744465_x_at
16863877
202014_PM_at
202014_at
23645
37028_PM_at
37028_at
3838005
3838006
3838007
3838008
3838009
3838010
3838011
3838013
3838014
3838015
3838016
4901426C_3p_s_at
8030128
A_14_P106853
GE81913
GO:0000164
GO:0005515
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006417
GO:0006915
GO:0006974
GO:0008157
GO:0012501
GO:0016020
GO:0019888
GO:0019901
GO:0023052
GO:0031400
GO:0032058
GO:0032515
GO:0032516
GO:0034976
GO:0035308
GO:0036211
GO:0036496
GO:0043226
GO:0045936
GO:0051726
GO:0070059
GO:0070972
GO:0072542
GO:0098772
GO:1902310
GO:1903898
GO:1903917
HMNXSV003017322
ILMN_1659936
PH_hs_0004421
TC19000711.hg
Participates
as an output of
Translation of PPP1R15A (Homo sapiens)
as a component of
GADD34:PP1CC [cytosol] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_055145.3
OpenTargets
ENSG00000087074
GeneCards
O75807
HPA
ENSG00000087074-PPP1R15A
Ensembl
ENSP00000200453
,
ENST00000200453
,
ENSG00000087074
PRO
O75807
Pharos - Targets
O75807
HMDB Protein
HMDBP14465
PDB
4XPN
,
7NZM
,
7NXV
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.819
12
UniProt:P05198 EIF2S1
2
p-S52-EIF2S1 [cytosol]
(R-HSA-381060)
EIF2S1 [cytosol]
(R-HSA-72510)
0.623
3
UniProt:Q13148 TADBP
0.597
10
UniProt:P56545 CTBP2
1
CTBP2 [nucleoplasm]
(R-HSA-5333990)
0.508
2
UniProt:Q13522 PPR1A
0.508
4
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