APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6

Stable Identifier
R-HSA-9007496
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6
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Expression of the pro-apoptotic APAF1 gene is directly stimulated by E2F1 binding to the APAF1 promoter. E2F6 can compete with E2F1 for the E2F binding site in the APAF1 promoter. Binding of E2F6 to the APAF1 promoter represses APAF1 transcription, which is implicated in suppression of growth-associated apoptosis in human hematopoietic progenitor cells (Kikuchi et al. 2007).
Literature References
PubMed ID Title Journal Year
17600109 E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1

Nakamura, M, Kikuchi, J, Ando, H, Furukawa, Y, Shimizu, R, Ozawa, K, Wada, T

Stem Cells 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
E2F6:(TFDP1,TFDP2):APAF1 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F6:(TFDP1,TFDP2) [nucleoplasm]
Positively by
Regulator
E2F1:(TFDP1,TFDP2):APAF1 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:(TFDP1,TFDP2) [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Herlihy, A  (2017-05-12)
Created
Orlic-Milacic, M  (2017-05-31)
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