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CYCS [cytosol]
Stable Identifier
R-BTA-53259
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
P62894
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Apoptotic factor-mediated response (Bos taurus)
Cytochrome c-mediated apoptotic response (Bos taurus)
Activation of caspases through apoptosome-mediated cleavage (Bos taurus)
Cleavage of Procaspase-3 by the apoptosome (Bos taurus)
Apoptosome [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
Cleavage of Procaspase-7 by the apoptosome (Bos taurus)
Apoptosome [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
Formation of apoptosome (Bos taurus)
CYCS binds to APAF1 (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
CYCS:APAF1 binds procaspase-9 (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
Cleavage of Procaspase‑9 to caspase‑9 (Bos taurus)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
Apoptosome [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
Procaspase 9 forms dimer (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
Regulation of the apoptosome activity (Bos taurus)
APAF1:CYCS binds APIP (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
APAF1:CYCS:ATP:APIP [cytosol] (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
CASP9 is phosphorylated at T412 (Bos taurus)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
APAF1:ATP:CYCS heptamer:p-T412-CASP9 [cytosol] (Bos taurus)
APAF1:ATP:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
XIAP binds CASP9 (Bos taurus)
Apoptosome [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
XIAP:apoptosome [cytosol] (Bos taurus)
Apoptosome [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
CYCS [cytosol] (Bos taurus)
Release of apoptotic factors from the mitochondria (Bos taurus)
Release of Cytochrome c from mitochondria (Bos taurus)
CYCS [cytosol] (Bos taurus)
Regulated Necrosis (Bos taurus)
Pyroptosis (Bos taurus)
Release of Cytochrome c from mitochondria (Bos taurus)
CYCS [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P62894
Reference Genes
BioGPS Gene:100847700
BioGPS Gene:510767
ENSEMBL:ENSBTAG00000022613
ENSEMBL:ENSBTAG00000022613.4
ENSEMBL:ENSBTAG00000023823.2
KEGG Gene (Bos taurus):100847700
KEGG Gene (Bos taurus):510767
Monarch:100847700
Monarch:510767
NCBI Gene:100847700
NCBI Gene:510767
Reference Transcript
RefSeq:XM_010804321.2
RefSeq:XM_010810497.2
RefSeq:NM_001046061.2
RefSeq:XM_005194019.3
Other Identifiers
510767
GO:0003824
GO:0006091
GO:0009055
GO:0016491
GO:0020037
Participates
as an input of
CYCS binds to APAF1 (Bos taurus)
as an output of
Release of Cytochrome c from mitochondria (Bos taurus)
as a component of
APAF1:ATP:CYCS [cytosol] (Bos taurus)
APAF1:CYCS [cytosol] (Bos taurus)
Other forms of this molecule
AcK-CYCS [mitochondrial intermembrane space]
CYCS [mitochondrial inner membrane]
CYCS [mitochondrial intermembrane space]
Inferred From
CYCS [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001039526.1
,
XP_010808799.1
,
XP_010802623.1
,
XP_005194076.1
ZINC target
P62894
Ensembl
ENSBTAG00000022613
,
ENSBTAP00000007918
,
ENSBTAT00000007918
PDB
6FF5
,
2B4Z
,
5JUY
,
3J2T
,
2YBB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14727 APAF1
4
APAF1 [secretory granule lumen]
(R-HSA-6801271)
APAF1 [extracellular region]
(R-HSA-6806465)
APAF1 [ficolin-1-rich granule lumen]
(R-HSA-6801301)
APAF1 [cytosol]
(R-HSA-50099)
0.736
14
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