TP53 stimulates APAF1 gene expression

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R-HSA-6791348
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Reaction [omitted]
Species
Homo sapiens
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Once bound to the p53 response element in the promoter of the APAF1 gene, TP53 (p53) stimulates APAF1 transcription (Robles et al. 2001). APAF1 participates in the intrinsic apoptosis pathway, where its interaction with cytochrome C mediates the autocatalytic activation of pro-caspase-9 (Hu et al. 1999).

Literature References
PubMed ID Title Journal Year
10393175 Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

Hu, Y, Benedict, MA, Ding, L, Nunez, G

EMBO J. 1999
11559530 APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

Robles, AI, Bemmels, NA, Foraker, AB, Harris, CC

Cancer Res. 2001
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