Reactome | MCPH1 sequesters condensin II

MCPH1 sequesters condensin II

Stable Identifier

R-HSA-2429719

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MCPH1 (microcephalin) binds condensin II complex through direct interaction with NCAPG2 and possibly NCAPD3 condensin II subunits (Wood et al. 2008, Yamashita et al. 2011). MCPH1 binding sequesters condensin II by preventing loading of condensin II on chromatin. Simultaneous binding of MCPH1 to the SET oncogene may contribute to condensin II sequestering (Leung et al. 2011). Mutations in MCPH1 are a cause of microchephaly inhereted in an autosomally recessive manner. MCPH1 deficient cells show premature chromosome condensation (PCC) phenotype, with metaphase-like chromosomes apparent in prophase, before nuclear envelope breakdown (Wood et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
21911480	MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II Yamashita, D, Shintomi, K, Ono, T, Gavvovidis, I, Schindler, D, Neitzel, H, Trimborn, M, Hirano, T	J. Cell Biol.	2011
21515671	SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation Leung, JW, Leitch, A, Wood, JL, Shaw-Smith, C, Metcalfe, K, Bicknell, LS, Jackson, AP, Chen, J	J. Biol. Chem.	2011
18718915	Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair Wood, JL, Liang, Y, Li, K, Chen, J	J. Biol. Chem.	2008