IL27:EBI3 [extracellular region]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

There is evidence that shows that when Interleukin-27 subunit beta (EBI3) coexpress with human Interleukin-27 subunit alpha while both can be secreted as a soluble complex (PMID:12121660)
Considering that cells expressing EBI3 keep this protein in the endoplasmic reticulum associated with calnexin, is suggested that subsequent processing and secretion to the extracellular region of EBI3 might be dependent on association with a second subunit, as Interleukin-27 subunit alpha (PMID : 9342359).

Literature References
PubMed ID Title Journal Year
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Devergne, O, Birkenbach, M, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Pflanz, S, Timans, JC, Cheung, J, Rosales, R, Kanzler, H, Gilbert, J, Hibbert, L, Churakova, T, Travis, M, Vaisberg, E, Blumenschein, WM, Mattson, JD, Wagner, JL, To, W, Zurawski, S, McClanahan, TK, Gorman, DM, Bazan, JF, de Waal Malefyt, R, Rennick, D, Kastelein, RA

Immunity 2002
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