IL27:EBI3

Stable Identifier
R-HSA-448442
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
Interleukin-27
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Summation

There is evidence that shows that when Interleukin-27 subunit beta (EBI3) coexpress with human Interleukin-27 subunit alpha while both can be secreted as a soluble complex (PMID:12121660)
Considering that cells expressing EBI3 keep this protein in the endoplasmic reticulum associated with calnexin, is suggested that subsequent processing and secretion to the extracellular region of EBI3 might be dependent on association with a second subunit, as Interleukin-27 subunit alpha (PMID : 9342359).

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