IL27:EBI3 [extracellular region]

Stable Identifier
R-HSA-448442
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-27
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General
There is evidence that shows that when Interleukin-27 subunit beta (EBI3) coexpress with human Interleukin-27 subunit alpha while both can be secreted as a soluble complex (PMID:12121660)
Considering that cells expressing EBI3 keep this protein in the endoplasmic reticulum associated with calnexin, is suggested that subsequent processing and secretion to the extracellular region of EBI3 might be dependent on association with a second subunit, as Interleukin-27 subunit alpha (PMID : 9342359).
Literature References
PubMed ID Title Journal Year
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Vaisberg, E, Gorman, DM, Timans, JC, Gilbert, J, Mattson, JD, Hibbert, L, Travis, M, Rennick, D, To, W, Kastelein, RA, Kanzler, H, Zurawski, S, Cheung, J, Rosales, R, Pflanz, S, Wagner, JL, Blumenschein, WM, Bazan, JF, de Waal Malefyt, R, Churakova, T, McClanahan, TK

Immunity 2002
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Birkenbach, M, Devergne, O, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
Participants
components
Participates
as an input of
as an output of
as a component of
Inferred To
IL27:EBI3 [extracellular region] (Bos taurus)
IL27:EBI3 [extracellular region] (Canis familiaris)
IL27:EBI3 [extracellular region] (Mus musculus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Sus scrofa)
IL27:EBI3 [extracellular region] (Xenopus tropicalis)
Cross References
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