IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane]

Stable Identifier
R-HSA-8950252
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
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General

Interleukin 27 phosphorylates/activates Tyrosine protein kinase JAK2 (JAK2) , non receptor tyrosine protein kinase TYK2 (TYK2) and Tyrosine protein kinase JAK1 (JAK1) (Kanda & Watanabe 2008). JAK1 interacts with IL27RA (Takeda et al 2003 )
As the phosphorylation required for Interleukin 27 induced activation are not clear, this is represented here as a black box event.

Literature References
PubMed ID Title Journal Year
18389480 IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes

Kanda, N, Watanabe, S

Eur. J. Immunol. 2008
Participants
components
Participates
as an input of
as an output of
Inferred To
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Bos taurus)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Danio rerio)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Mus musculus)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Sus scrofa)
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