IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane]

Stable Identifier
R-HSA-448431
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
Interleukin 27 subunit alpha: Interleukin-27 subunit beta: Interleukin-27 receptor subunit alpha:JAK2:Interleukin-6 receptor subunit beta:JAK1
General

Interleukin-27 (IL27) is an heterodimer composed by (IL27) and (EBI3). It binds to Interleukin-27 heterodimer, formed by Interleukin-27 receptor subunit alpha (IL27RA) and Interleukin-6 receptor subunit beta (IL6ST or gp130). Also in absence of IL27RA it can binds to the Interleukin-6 receptor subunit (IL6ST or gp130) but with lower affinity than to IL27 receptor heterodimer (PMID: 27119567)

Literature References
PubMed ID Title Journal Year
27119567 IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs

Jia, H, Dilger, P, Bird, C, Wadhwa, M

J. Interferon Cytokine Res. 2016
Participants
Participant Of
Inferred To