IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane]

Stable Identifier
R-HSA-448431
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin 27 subunit alpha: Interleukin-27 subunit beta: Interleukin-27 receptor subunit alpha:JAK2:Interleukin-6 receptor subunit beta:JAK1
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General
Interleukin-27 (IL27) is an heterodimer composed by (IL27) and (EBI3). It binds to Interleukin-27 heterodimer, formed by Interleukin-27 receptor subunit alpha (IL27RA) and Interleukin-6 receptor subunit beta (IL6ST or gp130). Also in absence of IL27RA it can binds to the Interleukin-6 receptor subunit (IL6ST or gp130) but with lower affinity than to IL27 receptor heterodimer (PMID: 27119567)
Literature References
PubMed ID Title Journal Year
27119567 IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs

Wadhwa, M, Dilger, P, Bird, C, Jia, H

J. Interferon Cytokine Res. 2016
Participants
components
Participates
as an output of
as an input of
Inferred To
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Bos taurus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Canis familiaris)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Mus musculus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Rattus norvegicus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Sus scrofa)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Xenopus tropicalis)
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