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EBI3 [extracellular region]
Stable Identifier
R-HSA-448418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Epstein-Barr virus-induced gene 3 protein, IL27B_HUMAN, IL27B, Interleukin-27 subunit beta
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
Interleukin-27 translocates from the ER lumen to the extracellular region (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35 binds IL6ST:IL6ST receptor (Homo sapiens)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
STAT1 associates with IL6ST:IL6ST (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
EBI3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14213 EBI3
Gene Names
EBI3, IL27B
Chain
signal peptide:1-20, chain:21-229
Reference Genes
BioGPS Gene:10148 EBI3
COSMIC (genes):EBI3 EBI3
CTD Gene:10148 EBI3
dbSNP Gene:10148 EBI3
ENSEMBL:ENSG00000105246 EBI3
HGNC:3129 EBI3
Monarch:10148 EBI3
NCBI Gene:10148 EBI3
OMIM:605816 EBI3
UCSC:Q14213 EBI3
Reference Transcript
RefSeq:NM_005755.2 EBI3
RefSeq:XM_011527619.2 EBI3
Other Identifiers
10148
11715346_at
16857136
219424_PM_at
219424_at
3817382
3817383
3817385
3817386
3817387
3817388
3817389
3817390
3817391
8024792
A_23_P119478
A_24_P370201
GE81553
GO:0002376
GO:0004896
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005886
GO:0006959
GO:0009897
GO:0016020
GO:0019221
GO:0019955
GO:0032729
GO:0042088
GO:0042098
GO:0043235
GO:0045523
GO:0046641
GO:0048018
GO:0060089
GO:0098772
HMNXSV003011301
ILMN_1802653
L08187_at
PH_hs_0026539
PH_hs_0034154
TC19000083.hg
g5031678_3p_at
Participates
as a component of
IL35 [extracellular region] (Homo sapiens)
IL27:EBI3 [extracellular region] (Homo sapiens)
Other forms of this molecule
EBI3 [endoplasmic reticulum lumen]
Inferred To
Ebi3 [extracellular region]
(Mus musculus)
Ebi3 [extracellular region]
(Rattus norvegicus)
ebi3 [extracellular region]
(Xenopus tropicalis)
EBI3 [extracellular region]
(Bos taurus)
EBI3 [extracellular region]
(Canis familiaris)
EBI3 [extracellular region]
(Sus scrofa)
Ghost homologue of EBI3 [extracellular region]
(Gallus gallus)
Cross References
ENSEMBL
ENSP00000221847
,
ENST00000221847
OpenTargets
ENSG00000105246
HPA
ENSG00000105246-EBI3
PRO
Q14213
Pharos - Targets
Q14213
GlyGen
Q14213
PDB
8D85
,
7U7N
,
7ZXK
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