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Ebi3 [extracellular region]
Stable Identifier
R-RNO-448418
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
EBI3, M0RD76
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-12 family signaling (Rattus norvegicus)
Interleukin-27 signaling (Rattus norvegicus)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Rattus norvegicus)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
Interleukin-27 translocates from the ER lumen to the extracellular region (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Rattus norvegicus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Rattus norvegicus)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
Interleukin-35 Signalling (Rattus norvegicus)
IL35 binds IL-12RB2:IL6ST receptor (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35 binds IL12RB2:IL12RB2 receptor (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35 binds IL6ST:IL6ST receptor (Rattus norvegicus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
Interleukin-35 translocates from the ER lumen to the extracellular region (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Rattus norvegicus)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Rattus norvegicus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Rattus norvegicus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Rattus norvegicus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Rattus norvegicus)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
STAT1 associates with IL6ST:IL6ST (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
p-STAT1 dissociates from IL6ST:IL6ST (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Rattus norvegicus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Rattus norvegicus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL35 [extracellular region] (Rattus norvegicus)
Ebi3 [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:M0RD76
Gene Names
Ebi3
Reference Genes
BioGPS Gene:680609 Ebi3
ENSEMBL:ENSRNOG00000050509
ENSEMBL:ENSRNOG00000050509.2 Ebi3
KEGG Gene (Rattus norvegicus):680609 Ebi3
Monarch:680609 Ebi3
NCBI Gene:680609 Ebi3
Reference Transcript
RefSeq:NM_001109421.1 Ebi3
Other Identifiers
10931537
1391453_at
17869355
5984490
5990522
6034539
6236530
6237445
6283934
6626182
6699012
6734955
680609
A_44_P1020757
A_64_P153159
GE1198974
GO:0002376
GO:0004896
GO:0005515
GO:0016020
GO:0023052
GO:0042098
GO:0045523
GO:0060089
PH_rn_0007958
rc_AA899612_at
Participates
as a component of
IL35 [extracellular region] (Rattus norvegicus)
IL27:EBI3 [extracellular region] (Rattus norvegicus)
Other forms of this molecule
Ebi3 [endoplasmic reticulum lumen]
Inferred From
EBI3 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001102891.1
Ensembl
ENSRNOG00000050509
,
ENSRNOT00000072031
,
ENSRNOP00000067573
RGD
1589467
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