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IL35 [extracellular region]
Stable Identifier
R-HSA-622267
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-35, IL12A:EBI3
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35 binds IL6ST:IL6ST receptor (Homo sapiens)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
STAT1 associates with IL6ST:IL6ST (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
General
Interleukin-35 can be secreted(PMID: 9342359) and be detected extracellularly and detected in serum samples as in comparative studies inRehumatoid arthritis (PMID: 26370008)
Literature References
PubMed ID
Title
Journal
Year
26370008
Low Serum Levels of Interleukin 35 in Patients with Rheumatoid Arthritis
Ning, X
,
Jian, Z
,
Wang, W
Tohoku J. Exp. Med.
2015
9342359
Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
Birkenbach, M
,
Devergne, O
,
Kieff, E
Proc. Natl. Acad. Sci. U.S.A.
1997
Participants
components
EBI3 [extracellular region]
(Homo sapiens)
IL12A [extracellular region]
(Homo sapiens)
Participates
as an input of
IL35 binds IL6ST:IL6ST receptor (Homo sapiens)
IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)
IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)
IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)
as a component of
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
as an output of
Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)
Inferred To
IL35 [extracellular region]
(Bos taurus)
IL35 [extracellular region]
(Canis familiaris)
IL35 [extracellular region]
(Gallus gallus)
IL35 [extracellular region]
(Mus musculus)
IL35 [extracellular region]
(Rattus norvegicus)
IL35 [extracellular region]
(Sus scrofa)
IL35 [extracellular region]
(Xenopus tropicalis)
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