Reactome | IL35 [extracellular region]

IL35

Stable Identifier

R-HSA-622267

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-35, IL12A:EBI3

Locations in the PathwayBrowser

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Summation

Interleukin-35 can be secreted(PMID: 9342359) and be detected extracellularly and detected in serum samples as in comparative studies inRehumatoid arthritis (PMID: 26370008)

Literature References

PubMed ID	Title	Journal	Year
9342359	Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin	Proc. Natl. Acad. Sci. U.S.A.	1997
26370008	Low Serum Levels of Interleukin 35 in Patients with Rheumatoid Arthritis	Tohoku J. Exp. Med.	2015

Participants

components

Participant Of

input

hasComponent

output

Interleukin-35 translocates from the ER lumen to the extracellular region

Inferred To

IL35 [extracellular region] (Bos taurus)

IL35 [extracellular region] (Canis familiaris)

IL35 [extracellular region] (Danio rerio)

IL35 [extracellular region] (Gallus gallus)

IL35 [extracellular region] (Mus musculus)

IL35 [extracellular region] (Rattus norvegicus)

IL35 [extracellular region] (Sus scrofa)

IL35 [extracellular region] (Taeniopygia guttata)

IL35 [extracellular region] (Xenopus tropicalis)