Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
EBI3 [extracellular region]
Stable Identifier
R-CFA-448418
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
EBI3, A0A8I3N258
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-12 family signaling (Canis familiaris)
Interleukin-27 signaling (Canis familiaris)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
Interleukin-27 binds Interleukin-27 receptor (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
Interleukin-27 dissociates from Interleukin-27 receptor (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
Interleukin-27 translocates from the ER lumen to the extracellular region (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Canis familiaris)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Canis familiaris)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
Interleukin-35 Signalling (Canis familiaris)
IL35 binds IL-12RB2:IL6ST receptor (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35 binds IL12RB2:IL12RB2 receptor (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35 binds IL27RA:IL12RB2 receptor (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35 binds IL6ST:IL6ST receptor (Canis familiaris)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
Interleukin-35 translocates from the ER lumen to the extracellular region (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Canis familiaris)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Canis familiaris)
IL35:(IL12RB2:JAK2 dimer) [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Canis familiaris)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
STAT1 associates with IL6ST:IL6ST (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
STAT4 binds IL12RB2:IL12RB2 (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
p-STAT1 dissociates from IL6ST:IL6ST (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Canis familiaris)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Canis familiaris)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Canis familiaris)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Canis familiaris)
IL35 [extracellular region] (Canis familiaris)
EBI3 [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N258
Gene Names
EBI3
Reference Genes
ENSEMBL:ENSCAFG00845006245.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006245.1 EBI3
Other Identifiers
485043
CfaAffx.29182.1.S1_at
GO:0004896
GO:0005515
GO:0016020
GO:0019221
GO:0023052
GO:0060089
Participates
as a component of
IL35 [extracellular region] (Canis familiaris)
IL27:EBI3 [extracellular region] (Canis familiaris)
Other forms of this molecule
EBI3 [endoplasmic reticulum lumen]
Inferred From
EBI3 [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000105246
Ensembl
ENSCAFG00845006245
,
ENSCAFP00845008638
,
ENSCAFT00845011071
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text