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EBI3 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8950622
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Interleukin-27 subunit beta, Epstein-Barr virus-induced gene 3
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
CANX binds EBI3 (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
CANX dissociates from IL27:EBI3 (Homo sapiens)
CANX:EBI3:IL27 [endoplasmic reticulum lumen] (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
IL27:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3:CANX binds IL27 (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
CANX:EBI3:IL27 [endoplasmic reticulum lumen] (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
Interleukin-27 translocates from the ER lumen to the extracellular region (Homo sapiens)
IL27:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
CANX dissociates from IL12A:EBI3 (Homo sapiens)
CANX:EBI3:IL12A [endoplasmic reticulum lumen] (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
IL12A:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 gene transcription and translation (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3:CANX binds IL12A (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
CANX:EBI3:IL12A [endoplasmic reticulum lumen] (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)
IL12A:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
General
Interleukin-27 subunit beta (EBI3) can be founded accumulated in the endoplasmic reticlum binded to Calnexin (PMID:9342359)
Literature References
PubMed ID
Title
Journal
Year
9342359
Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
Birkenbach, M
,
Devergne, O
,
Kieff, E
Proc. Natl. Acad. Sci. U.S.A.
1997
External Reference Information
External Reference
UniProt:Q14213 EBI3
Gene Names
EBI3, IL27B
Chain
signal peptide:1-20, chain:21-229
Reference Genes
BioGPS Gene:10148 EBI3
COSMIC (genes):EBI3 EBI3
CTD Gene:10148 EBI3
dbSNP Gene:10148 EBI3
ENSEMBL:ENSG00000105246 EBI3
HGNC:3129 EBI3
KEGG:hsa:10148 EBI3
Monarch:10148 EBI3
NCBI Gene:10148 EBI3
OMIM:605816 EBI3
UCSC:Q14213 EBI3
Reference Transcript
RefSeq:XM_011527619.2 EBI3
RefSeq:NM_005755.2 EBI3
Other Identifiers
10148
11715346_at
16857136
219424_PM_at
219424_at
3817382
3817383
3817385
3817386
3817387
3817388
3817389
3817390
3817391
8024792
A_23_P119478
A_24_P370201
GE81553
GO:0002376
GO:0004896
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005886
GO:0006959
GO:0009897
GO:0016020
GO:0019221
GO:0019955
GO:0032729
GO:0042088
GO:0042098
GO:0043235
GO:0045523
GO:0046641
GO:0048018
GO:0060089
GO:0098772
HMNXSV003011301
ILMN_1802653
L08187_at
PH_hs_0026539
PH_hs_0034154
TC19000083.hg
g5031678_3p_at
Participates
as an output of
EBI3 gene transcription and translation (Homo sapiens)
as a component of
IL12A:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
CANX:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
IL27:EBI3 [endoplasmic reticulum lumen] (Homo sapiens)
as an input of
CANX binds EBI3 (Homo sapiens)
Other forms of this molecule
EBI3 [extracellular region]
Inferred To
EBI3 [endoplasmic reticulum lumen]
(Bos taurus)
EBI3 [endoplasmic reticulum lumen]
(Canis familiaris)
EBI3 [endoplasmic reticulum lumen]
(Sus scrofa)
Ebi3 [endoplasmic reticulum lumen]
(Mus musculus)
Ebi3 [endoplasmic reticulum lumen]
(Rattus norvegicus)
ebi3 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSG00000105246
,
ENST00000221847
,
ENSP00000221847
OpenTargets
ENSG00000105246
GeneCards
EBI3
HPA
ENSG00000105246-EBI3
PRO
Q14213
Pharos - Targets
Q14213
GlyGen
Q14213
PDB
7ZXK
,
8D85
,
7U7N
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