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IL12B [extracellular region]
Stable Identifier
R-HSA-447181
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IL12p40, Interleukin-12 subunit beta, IL12B_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
IL12 bound to IL12R internalises (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [cytosol] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12B translocates from late endosome lumen to extracellular region (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12B translocates from the cytosol to the extracellular region (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12B:IL12B translocates from ER lumen to the extracellular region (Homo sapiens)
2xIL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)
2xIL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
Interleukin-12 dissociates from Interleukin-12 receptor (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
Interleukin-23 binds interleukin-23 receptor (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of IL13-downregulated extracellular proteins (Homo sapiens)
IL13-downregulated proteins [extracellular region] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
IL12B [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29460 IL12B
Gene Names
IL12B, NKSF2
Chain
signal peptide:1-22, chain:23-328
Reference Genes
BioGPS Gene:3593 IL12B
COSMIC (genes):IL12B IL12B
CTD Gene:3593 IL12B
dbSNP Gene:3593 IL12B
ENSEMBL:ENSG00000113302 IL12B
HGNC:5970 IL12B
KEGG Gene (Homo sapiens):3593 IL12B
Monarch:3593 IL12B
NCBI Gene:3593 IL12B
OMIM:161561 IL12B
UCSC:P29460 IL12B
Reference Transcript
RefSeq:NM_002187.2 IL12B
Other Identifiers
0005080184
11737833_at
11737834_at
17002328
207901_PM_at
207901_at
2884302
2884303
2884305
2884306
2884307
2884308
2884310
2884311
2884312
2884313
2884316
3593
563_at
8115570
A_23_P7560
GE58044
GO:0000003
GO:0001817
GO:0001916
GO:0002230
GO:0002323
GO:0002376
GO:0002827
GO:0002860
GO:0002862
GO:0003674
GO:0004896
GO:0005125
GO:0005126
GO:0005143
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005768
GO:0005783
GO:0005788
GO:0005829
GO:0005886
GO:0006464
GO:0006810
GO:0006950
GO:0007155
GO:0007165
GO:0007166
GO:0008083
GO:0008150
GO:0008219
GO:0008283
GO:0009897
GO:0009986
GO:0010033
GO:0010224
GO:0010536
GO:0015031
GO:0016020
GO:0016477
GO:0019221
GO:0019233
GO:0019953
GO:0019955
GO:0030101
GO:0030154
GO:0031410
GO:0031906
GO:0032693
GO:0032700
GO:0032725
GO:0032729
GO:0032733
GO:0032735
GO:0032740
GO:0032760
GO:0032816
GO:0032819
GO:0032946
GO:0032991
GO:0034105
GO:0034393
GO:0040011
GO:0042088
GO:0042093
GO:0042102
GO:0042104
GO:0042164
GO:0042509
GO:0042531
GO:0042802
GO:0042832
GO:0043226
GO:0043235
GO:0043382
GO:0043514
GO:0044877
GO:0045519
GO:0045672
GO:0045785
GO:0046982
GO:0048646
GO:0048662
GO:0048856
GO:0048870
GO:0050671
GO:0050709
GO:0050729
GO:0050829
GO:0050877
GO:0051135
GO:0051142
GO:0051607
GO:0070743
GO:0071222
GO:0071346
GO:1900747
GO:1901224
GO:1903588
GO:2000318
GO:2000330
HMNXSV003009674
ILMN_1669024
ILMN_1681132
M65290_at
PH_hs_0000077
TC05001997.hg
g4504640_3p_at
Participates
as a component of
IL12B:IL23A [extracellular region] (Homo sapiens)
2xIL12B [extracellular region] (Homo sapiens)
IL12A:IL12B [extracellular region] (Homo sapiens)
as an output of
IL12B translocates from the cytosol to the extracellular region (Homo sapiens)
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
This entity regulates
Negatively
Interleukin-12 binds Interleukin-12 receptor
(Homo sapiens)
Other forms of this molecule
IL12B [cytosol]
IL12B [Golgi lumen]
IL12B [late endosome lumen]
IL12B [endoplasmic reticulum lumen]
Inferred To
il12rb2l [extracellular region]
(Danio rerio)
Ghost homologue of IL12B [extracellular region]
(Bos taurus)
Ghost homologue of IL12B [extracellular region]
(Mus musculus)
lepr [extracellular region]
(Danio rerio)
IL12B [extracellular region]
(Canis familiaris)
IL12B [extracellular region]
(Gallus gallus)
IL12B [extracellular region]
(Sus scrofa)
Homologues of IL12B [extracellular region]
(Danio rerio)
Il12b [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_002178.2
OpenTargets
ENSG00000113302
GeneCards
P29460
HPA
ENSG00000113302-IL12B
Ensembl
ENSG00000113302
,
ENSP00000231228
,
ENST00000231228
PRO
P29460
Pharos - Targets
P29460
Orphanet
16254
PDB
5MXA
,
5MJ4
,
6UIB
,
1F42
,
4GRW
,
3D85
,
3QWR
,
3DUH
,
5MZV
,
3HMX
,
5NJD
,
6WDQ
,
5MJ3
,
3D87
,
1F45
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPF7 IL23A
2
IL23A [endoplasmic reticulum lumen]
(R-HSA-8950224)
IL23A [extracellular region]
(R-HSA-447245)
0.813
6
UniProt:P29459 IL12A
4
IL12A [Golgi lumen]
(R-HSA-8950463)
IL12A [endoplasmic reticulum lumen]
(R-HSA-8950139)
IL12A [late endosome lumen]
(R-HSA-8950449)
IL12A [extracellular region]
(R-HSA-447212)
0.609
2
UniProt:P29460 IL12B
5
IL12B [cytosol]
(R-HSA-8950760)
IL12B [Golgi lumen]
(R-HSA-8950359)
IL12B [late endosome lumen]
(R-HSA-8950675)
IL12B [endoplasmic reticulum lumen]
(R-HSA-8950126)
IL12B [extracellular region]
(R-HSA-447181)
0.524
2
UniProt:Q9EQ14 Il23a
2
Il23a [extracellular region]
(R-MMU-8950470)
Il23a [extracellular region]
(R-MMU-447245)
0.524
2
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