Homodimeric protein of Interleukin-12 beta subunit (IL12B or IL12p40) can be secreted to exert its inhibitory function over Interleukin-12 heterodimer interleukin-12 receptor interaction. The secretion has been shown experimentally in COS cells and by mean of ELISA assays (PMID: 7527811).
Stern, AS, Hollfelder, K, Su, C, Hakimi, J, Gubler, U, Gately, MK, Lin, P, Pan, YC, Ling, P
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