2xIL12B

Stable Identifier
R-HSA-8950640
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IL12B dimer
Locations in the PathwayBrowser
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Summation

Homodimeric protein of Interleukin-12 beta subunit (IL12B or IL12p40) can be secreted to exert its inhibitory function over Interleukin-12 heterodimer interleukin-12 receptor interaction. The secretion has been shown experimentally in COS cells and by mean of ELISA assays (PMID: 7527811).

Literature References
PubMed ID Title Journal Year
7527811 Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

Ling, P, Gately, MK, Gubler, U, Stern, AS, Lin, P, Hollfelder, K, Su, C, Pan, YC, Hakimi, J

J. Immunol. 1995
Participants
components
Participant Of
output
This entity regulates
Negative Regulation
Inferred To
2xIL12B [extracellular region] (Bos taurus)
2xIL12B [extracellular region] (Canis familiaris)
2xIL12B [extracellular region] (Danio rerio)
2xIL12B [extracellular region] (Gallus gallus)
2xIL12B [extracellular region] (Mus musculus)
2xIL12B [extracellular region] (Rattus norvegicus)
2xIL12B [extracellular region] (Sus scrofa)
2xIL12B [extracellular region] (Taeniopygia guttata)
2xIL12B [extracellular region] (Xenopus tropicalis)