Reactome | IL12A [late endosome lumen]

IL12A [late endosome lumen]

Stable Identifier

R-HSA-8950449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

late endosome lumen

Icon

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
26972013	The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells De Nardi, F, Galli, T, Benvenuti, F, Larghi, P, Müller, S, Piperno, GM, Jouve, M, Chiaruttini, G, Valitutti, S, Peden, AA, Baj, G	Cell Rep	2016

External Reference Information

External Reference

UniProt:P29459 IL12A

Gene Names

IL12A, NKSF1

Chain

signal peptide:1-22, chain:23-219

Reference Genes

BioGPS Gene:3592 IL12A

COSMIC (genes):IL12A IL12A

CTD Gene:3592 IL12A

dbSNP Gene:3592 IL12A

ENSEMBL:ENSG00000168811 IL12A

HGNC:5969 IL12A

Monarch:3592 IL12A

NCBI Gene:3592 IL12A

OMIM:161560 IL12A

UCSC:P29459 IL12A

Reference Transcript

RefSeq:NM_000882.3 IL12A

Other Identifiers

11756769_a_at

16947532

207160_PM_at

207160_at

2650068

2650069

2650070

2650071

2650072

2650073

2650074

2650075

2650076

2650077

2650078

2650079

2650080

2650081

2650082

33955_at

3592

7896725

8083690

A_14_P202111

A_23_P91943

GE519812

GO:0001916

GO:0002376

GO:0002860

GO:0005125

GO:0005143

GO:0005515

GO:0005576

GO:0005615

GO:0005788

GO:0006955

GO:0007165

GO:0008083

GO:0009615

GO:0010224

GO:0016477

GO:0031906

GO:0032496

GO:0032700

GO:0032729

GO:0032816

GO:0032946

GO:0034393

GO:0035722

GO:0042163

GO:0042531

GO:0043514

GO:0045513

GO:0045785

GO:0045954

GO:0046982

GO:0048018

GO:0048662

GO:0048870

GO:0050671

GO:0050709

GO:0050830

GO:0051135

GO:0097191

GO:0098542

GO:0098586

GO:0098772

GO:1900747

GO:1903588

GO:2000510

HMNXSV003038494

ILMN_1671353

M65291_at

PH_hs_0000076

TC03000870.hg

g4504638_3p_at

Participates

as a component of

IL12A:IL12B [late endosome lumen] (Homo sapiens)

Other forms of this molecule

IL12A [Golgi lumen]

IL12A [endoplasmic reticulum lumen]

IL12A [extracellular region]

Inferred To

IL12A [late endosome lumen] (Bos taurus)

IL12A [late endosome lumen] (Canis familiaris)

IL12A [late endosome lumen] (Gallus gallus)

IL12A [late endosome lumen] (Sus scrofa)

Il12a [late endosome lumen] (Mus musculus)

Il12a [late endosome lumen] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000514529, ENST00000699704

OpenTargets

ENSG00000168811

HPA

ENSG00000168811-IL12A

PRO

P29459

Pharos - Targets

P29459

GlyGen

P29459

Orphanet

IL12A

PDB

1F45, 3HMX

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29460 IL12B	5	IL12B [cytosol] (R-HSA-8950760) IL12B [Golgi lumen] (R-HSA-8950359) IL12B [late endosome lumen] (R-HSA-8950675) IL12B [endoplasmic reticulum lumen] (R-HSA-8950126) IL12B [extracellular region] (R-HSA-447181)	0.609	2
UniProt:Q96EA4 SPDL1	1	SPDL1 [cytosol] (R-HSA-377733)	0.527	2
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.527	2
UniProt:Q12841 FSTL1	3	FSTL1 [extracellular region] (R-HSA-201832) p-FSTL1 [endoplasmic reticulum lumen] (R-HSA-8957089) FSTL1 [endoplasmic reticulum lumen] (R-HSA-8956749)	0.527	2

© 2025 Reactome

Cite Us!