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IL12B [extracellular region]
Stable Identifier
R-CFA-447181
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
IL12B, A0A8I3MFA7
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-12 family signaling (Canis familiaris)
Interleukin-12 signaling (Canis familiaris)
IL12 bound to IL12R internalises (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12A:IL12B translocates from late endosome lumen to extracellular region (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12B translocates from the cytosol to the extracellular region (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12B:IL12B translocates from ER lumen to the extracellular region (Canis familiaris)
2xIL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
Interleukin-12 binds Interleukin-12 receptor (Canis familiaris)
2xIL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
Interleukin-12 dissociates from Interleukin-12 receptor (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
Interleukin-23 signaling (Canis familiaris)
IL12B:IL23A translocates from ER lumen to extracellular space (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
Interleukin-23 binds interleukin-23 receptor (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Canis familiaris)
IL12B:IL23A [extracellular region] (Canis familiaris)
IL12B [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MFA7
Gene Names
IL12B
Reference Genes
ENSEMBL:ENSCAFG00845001277.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845001277.1 IL12B
Reference Transcript
RefSeq:XM_014112766.1 IL12B
Other Identifiers
403976
CfaAffx.26444.1.S1_s_at
GO:0001916
GO:0002230
GO:0002376
GO:0002827
GO:0002860
GO:0002862
GO:0004896
GO:0005125
GO:0005126
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006954
GO:0007155
GO:0007166
GO:0008083
GO:0008283
GO:0009986
GO:0010033
GO:0010224
GO:0012501
GO:0016020
GO:0016477
GO:0023052
GO:0030101
GO:0030154
GO:0032693
GO:0032700
GO:0032725
GO:0032729
GO:0032733
GO:0032735
GO:0032740
GO:0032760
GO:0032816
GO:0032819
GO:0032946
GO:0034393
GO:0035722
GO:0036211
GO:0042093
GO:0042098
GO:0042102
GO:0042104
GO:0042164
GO:0042509
GO:0042531
GO:0042802
GO:0042832
GO:0043514
GO:0045519
GO:0045672
GO:0045785
GO:0046982
GO:0048018
GO:0048662
GO:0048856
GO:0048870
GO:0050671
GO:0050709
GO:0050829
GO:0051135
GO:0051142
GO:0051607
GO:0060089
GO:0070743
GO:0071222
GO:0071346
GO:0098542
GO:0098772
GO:1900747
GO:1903588
Participates
as a component of
IL12B:IL23A [extracellular region] (Canis familiaris)
2xIL12B [extracellular region] (Canis familiaris)
IL12A:IL12B [extracellular region] (Canis familiaris)
as an output of
IL12B translocates from the cytosol to the extracellular region (Canis familiaris)
This entity regulates
Negatively
Interleukin-12 binds Interleukin-12 receptor
(Canis familiaris)
Other forms of this molecule
IL12B [cytosol]
IL12B [late endosome lumen]
IL12B [endoplasmic reticulum lumen]
Inferred From
IL12B [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_013968241.1
OpenTargets
ENSG00000113302
Ensembl
ENSCAFP00845001755
,
ENSCAFT00845002222
,
ENSCAFG00845001277
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