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VIPR2 [plasma membrane]
Stable Identifier
R-HSA-420227
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Vasoactive intestinal polypeptide receptor 2, VIPR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Glucagon-type ligand receptors (Homo sapiens)
VIP receptors bind VIP (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
VIPR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41587 VIPR2
Gene Names
VIPR2, VIP2R
Chain
signal peptide:1-23, chain:24-438
Reference Genes
BioGPS Gene:7434 VIPR2
COSMIC (genes):VIPR2 VIPR2
CTD Gene:7434 VIPR2
dbSNP Gene:7434 VIPR2
ENSEMBL:ENSG00000106018 VIPR2
HGNC:12695 VIPR2
KEGG:hsa:7434 VIPR2
Monarch:7434 VIPR2
NCBI Gene:7434 VIPR2
OMIM:601970 VIPR2
UCSC:P41587 VIPR2
Reference Transcript
RefSeq:NM_001304522.1 VIPR2
RefSeq:NM_001308259.1 VIPR2
RefSeq:NM_003382.4 VIPR2
Other Identifiers
11731162_a_at
11731163_at
17065017
205946_PM_at
205946_at
205947_PM_s_at
205947_s_at
211598_PM_x_at
211598_x_at
3082372
3082374
3082375
3082379
3082380
3082388
3082389
3082390
3082391
3082392
3082397
3082404
3082419
3082426
3082435
3082439
3082450
3082452
3082453
3082454
3082455
38954_at
4049244
4049246
7434
8144213
A_23_P145978
A_32_P153071
GE60344
GO:0004888
GO:0004930
GO:0004999
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007188
GO:0007267
GO:0008528
GO:0016020
GO:0017046
GO:0023052
GO:0048662
GO:0060089
HMNXSV003035945
HMNXSV003055090
Hs.2126.0.S2_3p_at
ILMN_1683939
ILMN_1811133
PH_hs_0031976
TC07002085.hg
X95097_rna1_s_at
g4507898_3p_s_at
Participates
as a member of
VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
Inferred To
VIPR2 [plasma membrane]
(Bos taurus)
VIPR2 [plasma membrane]
(Canis familiaris)
VIPR2 [plasma membrane]
(Sus scrofa)
Vipr2 [plasma membrane]
(Mus musculus)
Vipr2 [plasma membrane]
(Rattus norvegicus)
VPAC2 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_003373.2
,
NP_001295188.1
,
NP_001291451.1
Guide to Pharmacology - Targets
372
OpenTargets
ENSG00000106018
ENSEMBL
ENSP00000262178
,
ENST00000262178
,
ENSG00000106018
,
ENSP00000366860
,
ENST00000377633
ZINC - Substances
VIPR2_HUMAN
ZINC target
P41587
PRO
P41587
GlyGen
P41587
PDB
2X57
,
7WBJ
,
7VQX
HPA
ENSG00000106018-VIPR2
GeneCards
VIPR2
Pharos - Targets
P41587
ZINC - Predictions - Purchasable
VIPR2_HUMAN
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53794 SLC5A3
1
SLC5A3 [plasma membrane]
(R-HSA-429592)
0.527
2
UniProt:Q9H5K3 POMK
1
POMK [endoplasmic reticulum membrane]
(R-HSA-8879120)
0.527
2
UniProt:P24468 NR2F2
1
NR2F2 [nucleoplasm]
(R-HSA-1183002)
0.527
2
UniProt:Q9Y3P9 RABGAP1
1
RABGAP1 [cytosol]
(R-HSA-8854144)
0.527
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.527
2
UniProt:Q9NXB9 ELOVL2
1
ELOVL2 [endoplasmic reticulum membrane]
(R-HSA-548677)
0.527
2
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.527
2
UniProt:O95427 PIGN
1
PIGN [endoplasmic reticulum membrane]
(R-HSA-162724)
0.527
2
UniProt:P03905 MT-ND4
1
MT-ND4 [mitochondrial inner membrane]
(R-HSA-60561)
0.527
3
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
2
UniProt:O75845 SC5D
1
SC5D [endoplasmic reticulum membrane]
(R-HSA-195662)
0.527
2
UniProt:P06576 ATP5F1B
6
ATP5F1B [mitochondrial matrix]
(R-HSA-164576)
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
0.527
3
UniProt:Q969Z0 TBRG4
1
TBRG4 [mitochondrial matrix]
(R-HSA-9837166)
0.527
2
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