Reactome | MPP5 [plasma membrane]

MPP5 [plasma membrane]

Stable Identifier

R-HSA-419969

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PALS1/MPP5, MAGUK p55 subfamily member 5, MPP5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P46937 YAP1

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External Reference Information

External Reference

UniProt:Q8N3R9 PALS1

Gene Names

PALS1, MPP5

Chain

chain:1-675

Reference Genes

BioGPS Gene:64398 PALS1

COSMIC - genes:MPP5 PALS1

CTD Gene:64398 PALS1

dbSNP Gene:64398 PALS1

ENSEMBL:ENSG00000072415 PALS1

HGNC:18669 PALS1

KEGG:hsa:64398 PALS1

Monarch:64398 PALS1

NCBI Gene:64398 PALS1

OMIM:606958 PALS1

UCSC:Q8N3R9 PALS1

Reference Transcript

Participates

as a component of

CRB3:PALS1:PATJ complex [plasma membrane] (Homo sapiens)

as an input of

Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)

Other forms of this molecule

MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Cross References

RefSeq

XP_005268060.1, NP_071919.2, XP_024305460.1, XP_047287649.1, XP_047287646.1, NP_001243479.1, XP_047287651.1, XP_047287647.1, XP_047287648.1, XP_024305459.1, XP_011535389.1, XP_011535388.1

OpenTargets

ENSG00000072415

ENSEMBL

ENST00000678380, ENSG00000072415, ENSP00000451488, ENST00000677382, ENSP00000503321, ENSP00000261681, ENST00000676464, ENST00000261681, ENST00000677835, ENSP00000503517, ENST00000555925, ENSP00000503322, ENSP00000503713

GeneCards

PALS1

HPA

ENSG00000072415-PALS1

PRO

Q8N3R9

Pharos - Targets

Q8N3R9

GlyGen

Q8N3R9

PDB

7NTK, 4UU5, 1Y76, 7NTJ, 3UIT, 4UU6, 4WSI, 7QCS, 7M4R

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14910 LIN7A	2	LIN7A [plasma membrane] (R-HSA-5216076) LIN7A [transport vesicle membrane] (R-HSA-9610413)	0.871	10
UniProt:P0DTC4 E	9	Ub-3xPalmC-E [virion membrane] (R-COV-9698416) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754)	0.846	7
UniProt:Q4VCS5 AMOT			0.802	7
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.8	7
UniProt:Q8NI35 PATJ	1	PATJ [plasma membrane] (R-HSA-420011)	0.784	6
UniProt:P82279 CRUM1			0.779	5
UniProt:Q9HAP6 LIN7B	2	LIN7B [transport vesicle membrane] (R-HSA-9610415) LIN7B [plasma membrane] (R-HSA-5216107)	0.742	6
UniProt:P59637 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9683652) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9683767) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683626) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683597) nascent E [endoplasmic reticulum lumen] (R-COV-9683684) Ub-3xPalmC-E [Golgi membrane] (R-COV-9683694) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698721) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698722) Ub-3xPalmC-E [virion membrane] (R-COV-9698716)	0.683	4
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.671	5
UniProt:Q96JB8 MPP4			0.625	5
UniProt:Q8N3R9 PALS1	2	MPP5 [plasma membrane] (R-HSA-419969) MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606)	0.592	2
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.581	4
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.556	3
UniProt:O95954 FTCD	1	FTCD [cytosol] (R-HSA-70907)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:A0A286YEY3 A0A286YEY3			0.556	3
UniProt:Q9Y2H0-1 DLGAP4			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9NY99-2 Q9NY992			0.556	3
UniProt:Q6PI77 GASP3			0.556	3
IntAct:EBI-23645769 CCSB ORF ID			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.527	4
UniProt:Q8IY63 AMOTL1	1	AMOTL1 [cytosol] (R-HSA-2028603)	0.527	3
UniProt:O75970 MPDZ			0.527	2
UniProt:P36809 VE6			0.525	2
UniProt:Q81964 Q81964			0.525	3
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.488	2

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