Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions

Stable Identifier
R-HSA-420661
Type
Reaction [binding]
Species
Homo sapiens
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The CRB3–Pals1–PATJ complex is the second major cell polarity protein complex at Tight Junctions (TJs) (Shin et al., 2006). The integral membrane protein CRB3 localizes to the apical domain of epithelial cells and is concentrated at TJs. CRB3 directly associates with Pals1 which interacts with PATJ, a proteins consisting of 10 PDZ domains. The interaction with CRB3 might recruit the Pals1-PATJ complex to TJs (Lemmers et al., 2002; Roh et al., 2003). Although its precise functions of the individual components have not been established, the complex is required for TJ formation, in part through the stabilization of apical and lateral components of tight junctions (Michel et al., 2005; Shin et al., 2005).

Literature References
PubMed ID Title Journal Year
11964389 hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells

Lemmers, C, Médina, E, Delgrossi, MH, Michel, D, Arsanto, JP, Le Bivic, A

J Biol Chem 2002
16129888 PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells

Michel, D, Arsanto, JP, Massey-Harroche, D, Beclin, C, Wijnholds, J, Le Bivic, A

J Cell Sci 2005
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