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NOP58 [nucleoplasm]
Stable Identifier
R-HSA-4570488
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleolar protein 58, NOP58_HUMAN, NOP5
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
18SE pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
47S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides (Homo sapiens)
Box C/D snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
SUMOylation of NOP58 with SUMO1 (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
SUMOylation of NOP58 with SUMO2 (Homo sapiens)
NOP58 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2X3 NOP58
Gene Names
NOP58, NOL5, NOP5, HSPC120
Chain
chain:1-529
Reference Genes
BioGPS Gene:51602 NOP58
COSMIC (genes):NOP58 NOP58
CTD Gene:51602 NOP58
dbSNP Gene:51602 NOP58
ENSEMBL:ENSG00000055044 NOP58
ENSEMBL_homo_sapiens_GENE:ENSG00000055044.11 NOP58
HGNC:29926 NOP58
KEGG Gene (Homo sapiens):51602 NOP58
Monarch:51602 NOP58
NCBI Gene:51602 NOP58
OMIM:616742 NOP58
UCSC:Q9Y2X3 NOP58
Reference Transcript
RefSeq:NM_015934.4 NOP58
Other Identifiers
11744098_at
11747090_a_at
16889602
223096_PM_at
223096_at
2523151
2523152
2523156
2523160
2523165
2523167
2523171
2523173
2523175
2523177
2523179
2523182
2523183
2523187
2523192
2523193
2523195
51602
53711_at
8047518
A_14_P110681
A_14_P202147
A_23_P154447
GE60555
GO:0001094
GO:0001650
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005732
GO:0005829
GO:0006364
GO:0015030
GO:0016020
GO:0030515
GO:0031428
GO:0032040
GO:0042254
GO:0042274
GO:0043226
GO:0048254
GO:0051117
GO:0070761
GO:1990904
HMNXSV003015704
ILMN_1748476
PH_hs_0006617
TC02001188.hg
g6841461_3p_at
Participates
as a component of
Box C/D snoRNP [nucleoplasm] (Homo sapiens)
U3 snoRNP [nucleoplasm] (Homo sapiens)
as an input of
SUMOylation of NOP58 with SUMO2 (Homo sapiens)
SUMOylation of NOP58 with SUMO1 (Homo sapiens)
Other forms of this molecule
polySUMO2-K467,K497-NOP58 [nucleoplasm]
monoSUMO1-K467,K497-NOP58 [nucleoplasm]
Inferred To
nol-58 [nucleoplasm]
(Caenorhabditis elegans)
nop5 [nucleoplasm]
(Drosophila melanogaster)
nop58 [nucleoplasm]
(Danio rerio)
nop58 [nucleoplasm]
(Dictyostelium discoideum)
nop58 [nucleoplasm]
(Schizosaccharomyces pombe)
nop58 [nucleoplasm]
(Xenopus tropicalis)
Nop58 [nucleoplasm]
(Mus musculus)
Nop58 [nucleoplasm]
(Rattus norvegicus)
NOP58 [nucleoplasm]
(Bos taurus)
NOP58 [nucleoplasm]
(Canis familiaris)
NOP58 [nucleoplasm]
(Gallus gallus)
NOP58 [nucleoplasm]
(Plasmodium falciparum)
NOP58 [nucleoplasm]
(Saccharomyces cerevisiae)
NOP58 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_057018.1
OpenTargets
ENSG00000055044
HPA
ENSG00000055044-NOP58
GeneCards
Q9Y2X3
Ensembl
ENSG00000055044
,
ENSP00000264279
,
ENST00000264279
PRO
Q9Y2X3
Pharos - Targets
Q9Y2X3
PDB
7MQA
,
7MQ8
,
7MQ9
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22087 FBL
1
FBL [nucleoplasm]
(R-HSA-6790638)
0.802
9
UniProt:Q96RS0 TGS1
2
TGS1 [cytosol]
(R-HSA-192209)
TGS1 [nucleoplasm]
(R-HSA-400176)
0.656
3
UniProt:O00567 NOP56
2
NOP56 [nucleoplasm]
(R-HSA-6790696)
NOP56 [cytosol]
(R-HSA-391293)
0.643
3
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.643
4
UniProt:Q9UHK0 NUFP1
0.597
3
UniProt:Q8N5I9 NOPC1
0.564
2
UniProt:P55769 SNU13
1
SNU13 [nucleoplasm]
(R-HSA-71887)
0.564
2
UniProt:Q9NWS0 PIHD1
0.527
2
UniProt:O43818 RRP9
1
RRP9 [nucleoplasm]
(R-HSA-6790682)
0.527
2
UniProt:Q8NA72 POC5
0.527
2
UniProt:Q9NWK9 BCD1
0.527
2
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.527
2
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.527
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.462
2
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