SUMO2-K467,K497-NOP58 [nucleoplasm]

Stable Identifier
R-HSA-4570460
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleolar protein 58, NOP58_HUMAN
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
20797634 Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif

Matic, I, Schimmel, J, Hendriks, IA, van Santen, MA, van de Rijke, F, van Dam, H, Gnad, F, Mann, M, Vertegaal, AC

Mol. Cell 2010
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
20797632 A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58

Westman, BJ, Verheggen, C, Hutten, S, Lam, YW, Bertrand, E, Lamond, AI

Mol. Cell 2010
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
21647297 A role for SUMOylation in snoRNP biogenesis revealed by quantitative proteomics

Westman, BJ, Lamond, AI

Nucleus 2011
External Reference Information
External Reference
UniProt:Q9Y2X3 NOP58
Gene Names
NOP58, NOL5, NOP5, HSPC120
Chain
chain:1-529
Reference Genes
BioGPS Gene:51602 NOP58
COSMIC (genes):NOP58 NOP58
CTD Gene:51602 NOP58
dbSNP Gene:51602 NOP58
ENSEMBL:ENSG00000055044 NOP58
HGNC:29926 NOP58
KEGG Gene (Homo sapiens):51602 NOP58
Monarch:51602 NOP58
NCBI Gene:51602 NOP58
OMIM:616742 NOP58
UCSC:Q9Y2X3 NOP58
Reference Transcript
Other Identifiers
0001980128
11744098_at
11747090_a_at
16889602
223096_at
2523151
2523152
2523156
2523160
2523165
2523167
2523171
2523173
2523175
2523177
2523179
2523182
2523183
2523187
2523192
2523193
2523195
51602
53711_at
8047518
A_14_P110681
A_14_P202147
A_23_P154447
GE60555
GO:0001094
GO:0001650
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005732
GO:0005737
GO:0005829
GO:0006364
GO:0008134
GO:0008150
GO:0015030
GO:0016020
GO:0019899
GO:0030515
GO:0031428
GO:0032040
GO:0032991
GO:0034641
GO:0042254
GO:0043226
GO:0048254
GO:0051117
GO:0070761
ILMN_1748476
PH_hs_0006617
TC02001188.hg
g6841461_3p_at
Participant Of
output
Other forms of this molecule
NOP58 [nucleoplasm]
SUMO1-K467,K497-NOP58 [nucleoplasm]
Inferred To
nop5 [nucleoplasm] (Drosophila melanogaster)
nop58 [nucleoplasm] (Danio rerio)
nop58 [nucleoplasm] (Xenopus tropicalis)
Nop58 [nucleoplasm] (Mus musculus)
Nop58 [nucleoplasm] (Rattus norvegicus)
SUMO2-K467,K497-NOP58 [nucleoplasm] (Bos taurus)
SUMO2-K467,K497-NOP58 [nucleoplasm] (Plasmodium falciparum)
NOP58 [nucleoplasm] (Canis familiaris)
NOP58 [nucleoplasm] (Gallus gallus)
NOP58 [nucleoplasm] (Sus scrofa)
Modified Residues
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 467
Coordinate
467
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 497
Coordinate
497
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
OpenTargets
HPA
GeneCards
Ensembl
PRO
Interactors (5)
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