Reactome | CASP8AP2 [nucleoplasm]

CASP8AP2 [nucleoplasm]

Stable Identifier

R-HSA-3927945

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CASP8-associated protein 2, C8AP2_HUMAN, FLASH

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UKL3 CASP8AP2

Gene Names

CASP8AP2, FLASH, KIAA1315, RIP25

Chain

initiator methionine:1, chain:2-1982

Reference Genes

BioGPS Gene:9994 CASP8AP2

COSMIC (genes):CASP8AP2 CASP8AP2

CTD Gene:9994 CASP8AP2

dbSNP Gene:9994 CASP8AP2

HGNC:1510 CASP8AP2

KEGG Gene (Homo sapiens):9994 CASP8AP2

Monarch:9994 CASP8AP2

NCBI Gene:9994 CASP8AP2

OMIM:606880 CASP8AP2

Reference Transcript

Participates

as an input of

Other forms of this molecule

monoSUMO1-K1813-CASP8AP2 [nucleoplasm]

Inferred To

Casp8ap2 [nucleoplasm] (Mus musculus)

Casp8ap2 [nucleoplasm] (Rattus norvegicus)

CASP8AP2 [nucleoplasm] (Bos taurus)

CASP8AP2 [nucleoplasm] (Canis familiaris)

CASP8AP2 [nucleoplasm] (Gallus gallus)

CASP8AP2 [nucleoplasm] (Sus scrofa)

casp8ap2 [nucleoplasm] (Danio rerio)

casp8ap2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001131139.1, NP_036247.1, NP_001131140.1

OpenTargets

ENSG00000118412

GeneCards

Q9UKL3

PRO

Q9UKL3

Pharos - Targets

Q9UKL3

GlyGen

Q9UKL3

PDB

2LR8, 6AP0, 6ANO, 6AOZ

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.704	5
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.602	5
UniProt:P63279 UBE2I	8	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619)	0.553	2
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.508	4

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