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CASP8AP2 [nucleoplasm]
Stable Identifier
R-HSA-3927945
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CASP8-associated protein 2, C8AP2_HUMAN, FLASH
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Homo sapiens)
CASP8AP2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
CASP8AP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKL3 CASP8AP2
Gene Names
CASP8AP2, FLASH, KIAA1315, RIP25
Chain
initiator methionine:1, chain:2-1982
Reference Genes
BioGPS Gene:9994 CASP8AP2
COSMIC (genes):CASP8AP2 CASP8AP2
CTD Gene:9994 CASP8AP2
dbSNP Gene:9994 CASP8AP2
HGNC:1510 CASP8AP2
KEGG Gene (Homo sapiens):9994 CASP8AP2
Monarch:9994 CASP8AP2
NCBI Gene:9994 CASP8AP2
OMIM:606880 CASP8AP2
Reference Transcript
RefSeq:NM_001137667.1 CASP8AP2
RefSeq:NM_012115.3 CASP8AP2
RefSeq:NM_001137668.1 CASP8AP2
Participant Of
input
PIAS1,4 SUMOylate CASP8AP2 with SUMO1
PRC1 SUMOylates CASP8AP2 with SUMO1
Other forms of this molecule
SUMO1-K1813-CASP8AP2 [nucleoplasm]
Inferred To
Casp8ap2 [nucleoplasm] (Mus musculus)
Casp8ap2 [nucleoplasm] (Rattus norvegicus)
CASP8AP2 [nucleoplasm] (Bos taurus)
CASP8AP2 [nucleoplasm] (Canis familiaris)
CASP8AP2 [nucleoplasm] (Gallus gallus)
CASP8AP2 [nucleoplasm] (Sus scrofa)
casp8ap2 [nucleoplasm] (Danio rerio)
casp8ap2 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_036247.1
,
NP_001131140.1
,
NP_001131139.1
OpenTargets
ENSG00000118412
GeneCards
Q9UKL3
PRO
Q9UKL3
PDB
6AP0
,
2LR8
,
6AOZ
,
6ANO
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14790 CASP8
8
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(217-374) [cytosol]
(R-HSA-75975)
0.704
5
UniProt:P23497 SP100
3
SUMO1-K297-SP100 [nucleoplasm]
(R-HSA-3000382)
SUMO2-K297-SP100 [nucleoplasm]
(R-HSA-3000454)
SP100 [nucleoplasm]
(R-HSA-1031705)
0.602
5
UniProt:P63279 UBE2I
8
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
0.553
2
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.508
4
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