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Receptor-type tyrosine-protein phosphatases
Stable Identifier
R-HSA-388844
DOI
10.3180/R-HSA-388844.1
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Receptor-type tyrosine-protein phosphatases (Homo sapiens)
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Like neurexins, Receptor-like protein tyrosine phosphatases (RPTPs) make trans-synaptic adhesion complexes with multiple postsynaptic binding partners to regulate synapse organization. The type IIa RPTPs include three members, Receptor-type tyrosine-protein phosphatase F (PTPRF) sometimes referred to as leukocyte common antigen-related (LAR), Receptor-type tyrosine-protein phosphatase sigma (PTPRS) and Receptor-type tyrosine-protein phosphatase delta (PTPRD). These proteins contain typical cell adhesion immunoglobulin-like (Ig) and fibronectin III (FNIII) domains, suggesting the involvement of RPTPs in cell-cell and cell-matrix interactions. To date, six different types of postsynaptic organizers for type-IIa RPTPs have been reported: interleukin-1 receptor accessory protein (IL1RAP, IL-1RAcP) (Yoshida et al. 2012), IL-1RAcP-like-1 (IL1RAPL1) (Yoshida et al. 2011), Neurotrophin receptor tyrosine kinase 3 (NTRK3, TrkC) (Takahashi et al. 2011), Leucine-rich repeat-containing protein 4B (LRRC4B, Netrin-G ligand-3, NGL-3) (Woo et al. 2009, Kwon et al. 2010), the Slit- and Trk-like (Slitrk) family proteins (Takahashi et al. 2012, Yim et al. 2013, Yamagata et al. 2015) and the liprins (Serra-Pagès et al. 1998, Dunah et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
23835198
Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization
Craig, AM
,
Takahashi, H
Trends Neurosci.
2013
Participants
Events
PTPRD binds IL1RAPL1
(Homo sapiens)
PTPRD binds IL1RAP-1
(Homo sapiens)
PTPRD binds SLITRK1-6
(Homo sapiens)
PTPRS binds NTRK3
(Homo sapiens)
PRTPRF, PTPRS, PTPRD bind LRRC4B
(Homo sapiens)
PTPRF, PTPRS, PTPRD bind Liprins
(Homo sapiens)
Participates
as an event of
Protein-protein interactions at synapses (Homo sapiens)
Orthologous Events
Receptor-type tyrosine-protein phosphatases (Bos taurus)
Receptor-type tyrosine-protein phosphatases (Caenorhabditis elegans)
Receptor-type tyrosine-protein phosphatases (Canis familiaris)
Receptor-type tyrosine-protein phosphatases (Danio rerio)
Receptor-type tyrosine-protein phosphatases (Drosophila melanogaster)
Receptor-type tyrosine-protein phosphatases (Gallus gallus)
Receptor-type tyrosine-protein phosphatases (Mus musculus)
Receptor-type tyrosine-protein phosphatases (Rattus norvegicus)
Receptor-type tyrosine-protein phosphatases (Sus scrofa)
Authored
Garapati, P V (2008-12-16)
Reviewed
Ko, J (2017-02-03)
Created
Garapati, P V (2008-12-16)
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