Reactome | PTPRD binds SLITRK1-6

PTPRD binds SLITRK1-6

Stable Identifier

R-HSA-6797803

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The SLIT and NTRK-like protein (SLITRK) family consists of six brain-specific transmembrane proteins (SLITRK1–6) that possess extracellular LRR domains homologous to the axon guidance molecule Slit and intracellular C-terminal tyrosine residues with surrounding sequences homologous to the Trk family (Aruga & Mikoshiba 2003). SLITRKs have been implicated in the modulation of neuronal process outgrowth promoting neuronal survival and in synapse formation (Linhoff et al. 2009). They exhibit synaptogenic activities through their interactions with specific LAR-RPTP members. All SLITRKs can interact with Receptor-type tyrosine-protein phosphatase delta (PTPRD), and SLIK1-3 at least can also interact with PTPRS (Meyer et al. 2004). SLITRK3 can induce inhibitory, but not excitatory, presynaptic differentiation whereas other family members induce both excitatory and inhibitory presynapses (Takahashi et al. 2012).
SLITRK1 variants are associated with Tourette’s syndrome (Abelson et al. 2005) and Trichotillomania (Zuchner et al. 2006) and obsessive compulsive disorders (OCDs). SLITRK2 is a candidate gene for schizophrenia (Piton et al. 2011) and bipolar disorder.

Literature References

PubMed ID	Title	Journal	Year
22286174	Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction Takahashi, H, Katayama, K, Sohya, K, Miyamoto, H, Prasad, T, Matsumoto, Y, Ota, M, Yasuda, H, Tsumoto, T, Aruga, J, Craig, AM	Nat. Neurosci.	2012
23345436	Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases Yim, YS, Kwon, Y, Nam, J, Yoon, HI, Lee, K, Kim, DG, Kim, E, Kim, CH, Ko, J	Proc. Natl. Acad. Sci. U.S.A.	2013