Reactome | PTPRF, PTPRS, PTPRD bind Liprins

PTPRF, PTPRS, PTPRD bind Liprins

Stable Identifier

R-HSA-388824

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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All the three LAR-RPTP transmembrane tyrosine phosphatases associate with liprin proteins and colocalize with liprin-alpha1 at the proximal edges of focal adhesions. Based on sequence similarities and binding characteristics, liprins are subdivided into alpha-type and beta-type liprins. The C-terminal, non-coiled coil regions of alpha-liprins bind to the membrane-distal phosphatase domains of LAR family members, as well as to the C-terminal, non-coiled coil region of beta-liprins. Liprin is required for normal presynaptic differentiation in C. elegans and controls synapse morphogenesis in Drosophila. In mammalian synapses the functional significance of liprin and LAR-RPTP interaction is unknown (Pages et al. 1998, Dunah et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15750591	LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses Dunah, AW, Hueske, E, Wyszynski, M, Hoogenraad, CC, Jaworski, J, Pak, DT, Simonetta, A, Liu, G, Sheng, M	Nat. Neurosci.	2005
7796809	The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions Serra-Pagès, C, Kedersha, NL, Fazikas, L, Medley, Q, Debant, A, Streuli, M	EMBO J	1995
9624153	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins Serra-Pagès, C, Medley, QG, Tang, M, Hart, A, Streuli, M	J Biol Chem	1998