Receptor protein tyrosine phosphatase delta (PTPRD) can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to interleukin-1 receptor accessory protein (IL1RAP) (Yoshida et al. 2012, Yamagata et al. 2015). IL1RAP has two distinct functions, one in immune regulation and inflammation by associating with IL1 and IL1R1 and another with PTPRD in synaptic adhesion and synapse organization (Dunne & O'Neill 2003).
Mishina, M, Chen, X, Lee, SJ, Uemura, T, Yasumura, M, Shiroshima, T, Iwakura, Y, Yoshida, T
Mishina, M, Maeda, A, Goto-Ito, S, Shiroshima, T, Uemura, T, Mori, H, Sato, Y, Yamagata, A, Iwasawa-Okamoto, S, Fukai, S, Yoshida, T
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