PTPRD binds IL1RAP-1

Stable Identifier
R-HSA-6800380
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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PTPRD binds IL1RAP-1
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Receptor protein tyrosine phosphatase delta (PTPRD) can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to interleukin-1 receptor accessory protein (IL1RAP) (Yoshida et al. 2012, Yamagata et al. 2015). IL1RAP has two distinct functions, one in immune regulation and inflammation by associating with IL1 and IL1R1 and another with PTPRD in synaptic adhesion and synapse organization (Dunne & O'Neill 2003).

Literature References
PubMed ID Title Journal Year
25908590 Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation

Yamagata, A, Yoshida, T, Sato, Y, Goto-Ito, S, Uemura, T, Maeda, A, Shiroshima, T, Iwasawa-Okamoto, S, Mori, H, Mishina, M, Fukai, S

Nat Commun 2015
22357843 Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule

Yoshida, T, Shiroshima, T, Lee, SJ, Yasumura, M, Uemura, T, Chen, X, Iwakura, Y, Mishina, M

J. Neurosci. 2012
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
PTPRD binds IL1RAP-1 (Canis familiaris)
PTPRD binds IL1RAP-1 (Gallus gallus)
PTPRD binds IL1RAP-1 (Mus musculus)
PTPRD binds IL1RAP-1 (Rattus norvegicus)
PTPRD binds IL1RAP-1 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Ko, J  (2017-02-03)
Created
Garapati, P V  (2015-09-29)