Reactome | PTPRD binds IL1RAP-1

PTPRD binds IL1RAP-1

Stable Identifier

R-HSA-6800380

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Receptor protein tyrosine phosphatase delta (PTPRD) can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to interleukin-1 receptor accessory protein (IL1RAP) (Yoshida et al. 2012, Yamagata et al. 2015). IL1RAP has two distinct functions, one in immune regulation and inflammation by associating with IL1 and IL1R1 and another with PTPRD in synaptic adhesion and synapse organization (Dunne & O'Neill 2003).

Literature References

PubMed ID	Title	Journal	Year
22357843	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule Mishina, M, Chen, X, Lee, SJ, Uemura, T, Yasumura, M, Shiroshima, T, Iwakura, Y, Yoshida, T	J. Neurosci.	2012
25908590	Mechanisms of splicing-dependent trans-synaptic adhesion by PTPÎ´-IL1RAPL1/IL-1RAcP for synaptic differentiation Mishina, M, Maeda, A, Goto-Ito, S, Shiroshima, T, Uemura, T, Mori, H, Sato, Y, Yamagata, A, Iwasawa-Okamoto, S, Fukai, S, Yoshida, T	Nat Commun	2015