PTPRS binds NTRK3

Stable Identifier
R-HSA-6798257
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Neurotrophin receptor 3 (NTRK3, TrkC) non-catalytic form acts as a synaptogenic adhesion molecule by binding to axonal Protein receptor-type tyrosine-protein phosphatase sigma (PTPRS). Transsynaptic interaction between dendritic NTRK3 and axonal PTPRS generates bidirectional non-catalytic signaling essential for excitatory pre- and postsynaptic differentiation in neural network development (Takahashi et al. 2011). The interaction between pre-synaptic PTPRS and post-synaptic NTRK3 involves extracellular domains of both proteins (Coles et al. 2014).

Literature References
PubMed ID Title Journal Year
25385546 Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis

Coles, CH, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, AW, Nakagawa, T, Craig, AM, Jones, EY, Aricescu, AR

Nat Commun 2014
21262467 Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex

Takahashi, H, Arstikaitis, P, Prasad, T, Bartlett, TE, Wang, YT, Murphy, TH, Craig, AM

Neuron 2011
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