Reactome | PTPRS binds NTRK3

PTPRS binds NTRK3

Stable Identifier

R-HSA-6798257

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Neurotrophin receptor 3 (NTRK3, TrkC) non-catalytic form acts as a synaptogenic adhesion molecule by binding to axonal Protein receptor-type tyrosine-protein phosphatase sigma (PTPRS). Transsynaptic interaction between dendritic NTRK3 and axonal PTPRS generates bidirectional non-catalytic signaling essential for excitatory pre- and postsynaptic differentiation in neural network development (Takahashi et al. 2011). The interaction between pre-synaptic PTPRS and post-synaptic NTRK3 involves extracellular domains of both proteins (Coles et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
21262467	Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex Takahashi, H, Arstikaitis, P, Prasad, T, Bartlett, TE, Wang, YT, Murphy, TH, Craig, AM	Neuron	2011
25385546	Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis Coles, CH, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, AW, Nakagawa, T, Craig, AM, Jones, EY, Aricescu, AR	Nat Commun	2014