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Protein-protein interactions at synapses
Stable Identifier
R-HSA-6794362
DOI
10.3180/R-HSA-6794362.1
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
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Synapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newly formed contacts. Synapse assembly and maintenance invokes heterophilic presynaptic and postsynaptic transmembrane proteins that bind each other in the extracellular space and recruit additional proteins via their intracellular domains. Members of the cadherin and immunoglobulin (Ig) superfamilies are thought to mediate this function. Several molecules, including synaptic cell-adhesion molecule (SynCAM), N-cadherin, neural cell-adhesion molecule (NCAM), Eph receptor tyrosine kinases, and neuroligins and neurexins, have been implicated in synapse formation and maintenance (Dean & Dresbach 2006, Craig et al. 2006, Craig & Kang 2007, Sudhof 2008).
Literature References
PubMed ID
Title
Journal
Year
17299456
Cell adhesion molecules: signalling functions at the synapse
McClelland, AC
,
Dalva, MB
,
Kayser, MS
Nat. Rev. Neurosci.
2007
16337696
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function
Dresbach, T
,
Dean, C
Trends Neurosci.
2006
18923512
Neuroligins and neurexins link synaptic function to cognitive disease
Südhof, TC
Nature
2008
Participants
Events
Neurexins and neuroligins
(Homo sapiens)
Receptor-type tyrosine-protein phosphatases
(Homo sapiens)
Synaptic adhesion-like molecules
(Homo sapiens)
Participates
as an event of
Neuronal System (Homo sapiens)
Orthologous Events
Protein-protein interactions at synapses (Bos taurus)
Protein-protein interactions at synapses (Caenorhabditis elegans)
Protein-protein interactions at synapses (Canis familiaris)
Protein-protein interactions at synapses (Danio rerio)
Protein-protein interactions at synapses (Drosophila melanogaster)
Protein-protein interactions at synapses (Gallus gallus)
Protein-protein interactions at synapses (Mus musculus)
Protein-protein interactions at synapses (Rattus norvegicus)
Protein-protein interactions at synapses (Sus scrofa)
Protein-protein interactions at synapses (Xenopus tropicalis)
Authored
Garapati, P V (2015-09-04)
Reviewed
Washbourne, P (2015-11-09)
Created
Garapati, P V (2015-09-04)
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