PRTPRF, PTPRS, PTPRD bind LRRC4B

Stable Identifier
R-HSA-6798258
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PRTPRF, PTPRS, PTPRD bind LRRC4B
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Leucine-rich repeat-containing protein 4B (LRRC4B, NGL-3) is a member of the netrin-G ligand (NGL, LRRC4) family that is widely expressed in the brain. LRRC4B binds with high affinity to Protein tyrosine Receptor-type tyrosine-protein phosphatase F (PTPRF, LAR), Protein tyrosine Receptor-type tyrosine-protein phosphatase sigma (PTPRS) and Protein tyrosine Receptor-type tyrosine-protein phosphatase delta (PTPRD). It binds to the first two fibronectin III (FnIII) domains of the PTPRs, thus it is likely to interact with all PTPRs splice variants. LRRC4B may induce both excitatory and inhibitory presynaptic differentiation in contacting axons (Woo et al. 2009, 2010).
Literature References
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Orthologous Events
PRTPRF, PTPRS, PTPRD bind LRRC4B (Bos taurus)
PRTPRF, PTPRS, PTPRD bind LRRC4B (Canis familiaris)
PRTPRF, PTPRS, PTPRD bind LRRC4B (Drosophila melanogaster)
PRTPRF, PTPRS, PTPRD bind LRRC4B (Mus musculus)
PRTPRF, PTPRS, PTPRD bind LRRC4B (Rattus norvegicus)
PRTPRF, PTPRS, PTPRD bind LRRC4B (Sus scrofa)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Ko, J  (2017-02-03)
Created
Garapati, P V  (2015-09-17)
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