Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CFI(340-583) [extracellular region]
Stable Identifier
R-HSA-976750
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Complement factor I light chain, CFI, CFAI_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Complement factor I binds C4BP (Homo sapiens)
C4b-binding protein:Factor I [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI:CFH:C3b [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI:CFH,FHR3:C3b [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Complement factor I complex formation (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Complement factor I inactivates C4BP-bound C4b (Homo sapiens)
C4b-binding protein:Factor I [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Factor I cleaves iC3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Factor I inactivates Factor H-boundC3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI:CFH,FHR3:C3b [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI:CFH,FHR3:iC3b [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
CFI:CFH:C3b [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(340-583) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05156 CFI
Gene Names
CFI, IF
Chain
signal peptide:1-18, chain:19-583, chain:19-335, chain:340-583
Reference Genes
COSMIC (genes):CFI CFI
dbSNP Gene:3426 CFI
ENSEMBL:ENSG00000205403 CFI
Participates
as an input of
Complement factor I complex formation (Homo sapiens)
as a component of
CFI [extracellular region] (Homo sapiens)
Other forms of this molecule
CFI(19-335) [extracellular region]
Inferred To
Dmel\CG8172 [extracellular region]
(Drosophila melanogaster)
SP54 [extracellular region]
(Drosophila melanogaster)
flz [extracellular region]
(Drosophila melanogaster)
Np [extracellular region]
(Drosophila melanogaster)
CFI [extracellular region]
(Bos taurus)
CFI [extracellular region]
(Canis familiaris)
CFI [extracellular region]
(Sus scrofa)
SP108 [extracellular region]
(Drosophila melanogaster)
Sb [extracellular region]
(Drosophila melanogaster)
CFI(340-583) [extracellular region]
(Gallus gallus)
CFI(340-583) [extracellular region]
(Mus musculus)
CFI(340-583) [extracellular region]
(Rattus norvegicus)
SP67 [extracellular region]
(Drosophila melanogaster)
Homologues of CFI(340-583) [extracellular region]
(Drosophila melanogaster)
cfi [extracellular region]
(Xenopus tropicalis)
Dmel\CG32755 [extracellular region]
(Drosophila melanogaster)
Corin [extracellular region]
(Drosophila melanogaster)
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01024-PRO_0000005911 C3
0.854
9
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.73
6
UniProt:P08603-2 CFH
0.623
2
UniProt:P08603-1 CFH
0.623
5
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text