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CFI(19-335) [extracellular region]
Stable Identifier
R-HSA-976782
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Complement factor I heavy chain, CFI, CFAI_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Complement factor I binds C4BP (Homo sapiens)
C4b-binding protein:Factor I [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI:CFH:C3b [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI:CFH,FHR3:C3b [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Complement factor I complex formation (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Complement factor I inactivates C4BP-bound C4b (Homo sapiens)
C4b-binding protein:Factor I [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Factor I cleaves iC3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Factor I inactivates Factor H-boundC3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI:CFH,FHR3:C3b [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI:CFH,FHR3:iC3b [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
CFI:CFH:C3b [extracellular region] (Homo sapiens)
CFI [extracellular region] (Homo sapiens)
CFI(19-335) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05156 CFI
Gene Names
CFI, IF
Chain
signal peptide:1-18, chain:19-583, chain:19-335, chain:340-583
Reference Genes
BioGPS Gene:3426 CFI
COSMIC (genes):CFI CFI
CTD Gene:3426 CFI
dbSNP Gene:3426 CFI
ENSEMBL:ENSG00000205403.15 CFI
HGNC:5394 CFI
KEGG Gene (Homo sapiens):3426 CFI
Monarch:3426 CFI
NCBI Gene:3426 CFI
OMIM:217030 CFI
UCSC:P05156 CFI
Reference Transcript
RefSeq:NM_000204.4 CFI
RefSeq:NM_001331035.1 CFI
Other Identifiers
11718481_s_at
11753068_a_at
1555564_PM_a_at
1555564_a_at
16978976
203854_PM_at
203854_at
2781742
2781743
2781744
2781745
2781746
2781748
2781750
2781751
2781752
2781753
2781755
2781757
2781758
2781762
2781766
2781767
2781771
3426
35698_at
8102328
A_23_P7212
A_24_P92472
GE60229
GO:0002376
GO:0003824
GO:0004252
GO:0005044
GO:0005515
GO:0005576
GO:0005615
GO:0006508
GO:0006897
GO:0006956
GO:0006958
GO:0008233
GO:0008236
GO:0016020
GO:0016192
GO:0016787
GO:0038024
GO:0043226
GO:0045087
GO:0046872
GO:0070062
GO:0098542
GO:0140096
HMNXSV003027747
HMNXSV003037765
Hs2.36602.2.S1_3p_s_at
ILMN_1727815
PH_hs_0023733
TC04001466.hg
Y00318_at
g4504578_3p_at
Participates
as an input of
Complement factor I complex formation (Homo sapiens)
as a component of
CFI [extracellular region] (Homo sapiens)
Other forms of this molecule
CFI(340-583) [extracellular region]
Inferred To
cfi [extracellular region]
(Xenopus tropicalis)
Dmel\CG32755 [extracellular region]
(Drosophila melanogaster)
CFI [extracellular region]
(Bos taurus)
CFI [extracellular region]
(Sus scrofa)
CFI(19-335) [extracellular region]
(Canis familiaris)
CFI(19-335) [extracellular region]
(Danio rerio)
CFI(19-335) [extracellular region]
(Gallus gallus)
CFI(19-335) [extracellular region]
(Mus musculus)
CFI(19-335) [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000195.2
,
NP_001317964.1
OpenTargets
ENSG00000205403
IntEnz
3.4.21.45
HPA
ENSG00000205403-CFI
GeneCards
P05156
Ensembl
ENSP00000378130
,
ENSG00000205403
,
ENST00000394634
PRO
P05156
Pharos - Targets
P05156
Orphanet
15438
PDB
2XRC
,
5O32
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01024-PRO_0000005911 C3
0.854
9
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.73
6
UniProt:P08603-2 CFH
0.623
2
UniProt:P08603-1 CFH
0.623
5
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