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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
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Tissue Distribution
Diseases
Cytomics
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Curator Guide
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FAQ
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Citing us
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PDGFA-2 [extracellular region]
Stable Identifier
R-HSA-380739
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PDGFA isoform 2, Platelet-derived growth factor A chain isoform 2, Active PDGF A-chain isoform 2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Autophosphorylation of PDGF alpha receptors (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)
PDGF alpha/beta:PDGF AB and BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Downstream signal transduction (Homo sapiens)
Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Activation of Src (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Crk binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
GRB2:SOS1 complex binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Grb7 binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Nck binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PI3-kinase binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PLC-gamma binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
Phosphorylation of PLCgamma by PDGFR (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
SH2 domain of Src binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
SHP2 binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
STAT binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF dimer binds two receptors simultaneously (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF:PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF-AA clevage by Furin (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGF-AB clevage by Furin (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGFRs bind type I TKI (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
p-PDGFRB homo and heterodimers [plasma membrane] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers dephosphorylated at Y1021 of PDGFRB [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFA-2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04085-2 PDGFA
Gene Names
PDGFA, PDGF1
Participates
as a member of
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
as a component of
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
Other forms of this molecule
PDGFA-2 [endoplasmic reticulum lumen]
N-ter PDGFA-2 fragment [Golgi lumen]
PDGFA-2 [Golgi membrane]
Inferred To
Pdgfa [extracellular region]
(Mus musculus)
Pdgfa [extracellular region]
(Rattus norvegicus)
Pvf1 [extracellular region]
(Drosophila melanogaster)
PDGFA [extracellular region]
(Bos taurus)
PDGFA [extracellular region]
(Canis familiaris)
PDGFA [extracellular region]
(Sus scrofa)
pdgfab [extracellular region]
(Danio rerio)
PDGF-A (L) [extracellular region]
(Gallus gallus)
pvf-1 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001382295.1
,
XP_054214342.1
,
XP_047276413.1
,
NP_002598.4
,
NP_148983.1
ENSEMBL
ENSP00000346508
,
ENSP00000383889
,
ENSG00000197461
,
ENST00000354513
,
ENST00000402802
OpenTargets
ENSG00000197461
GeneCards
PDGFA
HPA
ENSG00000197461-PDGFA
ZINC - Substances
PDGFA_HUMAN
ZINC target
P04085
PRO
P04085
Pharos - Targets
P04085
GlyGen
P04085
ZINC - Predictions - Purchasable
PDGFA_HUMAN
PDB
3MJK
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16234 PDGFRA
20
PDGFRA L629P [plasma membrane]
(R-HSA-9673596)
PDGFRA N659K [plasma membrane]
(R-HSA-9671535)
PDGFRA T674I [plasma membrane]
(R-HSA-9673603)
PDGFRA S601P [plasma membrane]
(R-HSA-9673600)
PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9671971)
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673609)
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9672027)
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673634)
PDGFRA D842_M844del [plasma membrane]
(R-HSA-9671526)
PDGFRA D842Y [plasma membrane]
(R-HSA-9671956)
PDGFRA D842V [plasma membrane]
(R-HSA-9671549)
PDGFRA I843_D846del [plasma membrane]
(R-HSA-9671537)
PDGFRA D842_H845del [plasma membrane]
(R-HSA-9671545)
PDGFRA D842del [plasma membrane]
(R-HSA-9671538)
PDGFRA D842_I843delinsV [plasma membrane]
(R-HSA-9671563)
PDGFRA D846Y [plasma membrane]
(R-HSA-9671958)
PDGFRA D843_845del [plasma membrane]
(R-HSA-9671552)
PDGFRA D842_D846del [plasma membrane]
(R-HSA-9671547)
PDGFRA N848K [plasma membrane]
(R-HSA-9671961)
PDGFRA Y849C [plasma membrane]
(R-HSA-9671974)
0.691
6
UniProt:P09619 PDGFRB
3
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
0.524
5
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