Reactome | PDGFA-2 [endoplasmic reticulum lumen]

PDGFA-2 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-381916

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

PDGFA isoform 2 precursor, Platelet-derived growth factor A chain precursor

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04085-2 PDGFA

Gene Names

PDGFA, PDGF1

Participates

as a component of

PDGF AB precursor heterodimer [endoplasmic reticulum lumen] (Homo sapiens)

as a member of

PDGF A isoforms [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

N-ter PDGFA-2 fragment [Golgi lumen]

PDGFA-2 [Golgi membrane]

PDGFA-2 [extracellular region]

Inferred To

PDGF-A (L) [endoplasmic reticulum lumen] (Gallus gallus)

PDGFA [endoplasmic reticulum lumen] (Bos taurus)

PDGFA [endoplasmic reticulum lumen] (Canis familiaris)

PDGFA [endoplasmic reticulum lumen] (Sus scrofa)

Pdgfa [endoplasmic reticulum lumen] (Mus musculus)

Pdgfa [endoplasmic reticulum lumen] (Rattus norvegicus)

pdgfab [endoplasmic reticulum lumen] (Danio rerio)

pvf-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Pvf1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_148983.1, NP_002598.4

ENSEMBL

ENST00000354513, ENSP00000383889, ENST00000402802, ENSG00000197461, ENSP00000346508

OpenTargets

ENSG00000197461

GeneCards

PDGFA

HPA

ENSG00000197461-PDGFA

ZINC - Substances

PDGFA_HUMAN

ZINC target

P04085

PRO

P04085

Pharos - Targets

P04085

GlyGen

P04085

ZINC - Predictions - Purchasable

PDGFA_HUMAN

PDB

3MJK

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.691	6
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.524	5

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