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PDGFA [extracellular region]
Stable Identifier
R-BTA-380739
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
PDGFA-2, Q2KJ15
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
Autophosphorylation of PDGF alpha receptors (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Autophosphorylation of PDGF alpha/beta receptors (Bos taurus)
PDGF alpha/beta:PDGF AB and BB dimers [plasma membrane] (Bos taurus)
PDGF AB or BB homodimers [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Bos taurus)
PDGF AB or BB homodimers [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Downstream signal transduction (Bos taurus)
Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Activation of Src (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Crk binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
GRB2:SOS1 complex binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Grb7 binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Nck binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PI3-kinase binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PLC-gamma binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Phosphorylation of PLCgamma by PDGFR (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
SH2 domain of Src binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
SHP2 binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
STAT binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
p130Cas and C3G bind PDGFR bound Crk (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF dimer binds two receptors simultaneously (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF-AB clevage by Furin (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGFRs bind type I TKI (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)
p-PDGFRB homo and heterodimers [plasma membrane] (Bos taurus)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Bos taurus)
PDGF AB or BB homodimers [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] (Bos taurus)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers dephosphorylated at Y1021 of PDGFRB [plasma membrane] (Bos taurus)
PDGF AB or BB homodimers [extracellular region] (Bos taurus)
PDGF A/B heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:Q2KJ15
Gene Names
PDGFA
Reference Genes
BioGPS Gene:505908 PDGFA
ENSEMBL:ENSBTAG00000014541
KEGG:bta:505908 PDGFA
Monarch:505908 PDGFA
NCBI Gene:505908 PDGFA
UCSC:Q2KJ15 PDGFA
Reference Transcript
RefSeq:XM_059881191.1 PDGFA
RefSeq:NM_001075231.1 PDGFA
RefSeq:XM_024984702.2 PDGFA
RefSeq:XM_024984701.2 PDGFA
Participates
as a component of
PDGF A/B heterodimer [extracellular region] (Bos taurus)
Other forms of this molecule
PDGFA [platelet alpha granule lumen]
PDGFA [endoplasmic reticulum lumen]
PDGFA [endoplasmic reticulum lumen]
PDGFA [Golgi lumen]
PDGFA [Golgi membrane]
PDGFA [Golgi membrane]
PDGFA [extracellular region]
Inferred From
PDGFA-2 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_024840470.1
,
XP_024840469.1
,
XP_059737174.1
,
NP_001068699.1
VGNC
32689
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