Reactome | Pdgfa [extracellular region]

Pdgfa [extracellular region]

Stable Identifier

R-MMU-380739

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

PDGFA-2, P20033

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - RAS GEFs promote RAS nucleotide exchange (Mus musculus)
        
        RAS GEFs [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by PDGF (Mus musculus)
    - Autophosphorylation of PDGF alpha receptors (Mus musculus)
      - PDGF alpha receptor: PDGF dimers [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Mus musculus)
        
        PDGF alpha receptor: PDGF dimers [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
    - Autophosphorylation of PDGF alpha/beta receptors (Mus musculus)
      - PDGF alpha/beta:PDGF AB and BB dimers [plasma membrane] (Mus musculus)
        
        PDGF AB or BB homodimers [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Mus musculus)
        
        PDGF AB or BB homodimers [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
    - Downstream signal transduction (Mus musculus)
      - Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - Activation of Src (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - Crk binds to the active PDGF receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - GRB2:SOS1 complex binds to the active receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - Grb7 binds to the active PDGF receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - Nck binds to the active PDGF receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - PI3-kinase binds to the active receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - PLC-gamma binds to the active receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - Phosphorylation of PLCgamma by PDGFR (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - SH2 domain of Src binds to the active receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - SHP2 binds to the active receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - STAT binds to the active receptor (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - p130Cas and C3G bind PDGFR bound Crk (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Mus musculus)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
    - PDGF dimer binds two receptors simultaneously (Mus musculus)
      - Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - PDGF:PDGF receptor dimer [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
    - PDGF-AB clevage by Furin (Mus musculus)
      - PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
    - PDGFRs bind type I TKI (Mus musculus)
      - PDGF alpha receptor: PDGF dimers [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Mus musculus)
        
        PDGF alpha receptor: PDGF dimers [plasma membrane] (Mus musculus)
        
        Active PDGF dimers (AA, AB, BB) [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
    - PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)
      - p-PDGFRB homo and heterodimers [plasma membrane] (Mus musculus)
        
        Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Mus musculus)
        
        PDGF AB or BB homodimers [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)
      - p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] (Mus musculus)
        
        Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers dephosphorylated at Y1021 of PDGFRB [plasma membrane] (Mus musculus)
        
        PDGF AB or BB homodimers [extracellular region] (Mus musculus)
        
        PDGF A/B heterodimer [extracellular region] (Mus musculus)
        
        Pdgfa [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P20033

Gene Names

Pdgfa

Reference Genes

BioGPS Gene:18590 Pdgfa

ENSEMBL:ENSMUSG00000025856

KEGG:mmu:18590 Pdgfa

Monarch:18590 Pdgfa

NCBI Gene:18590 Pdgfa

UCSC:P20033 Pdgfa

Reference Transcript

Other Identifiers

10535043

109416_at

1418711_at

1449187_at

17454345

18590

4382518

4404634

4405320

4405935

4509589

4528543

4549029

4780673

4836058

4914782

4951924

5158676

5160508

5436005

5479781

5567348

5614105

94932_at

A_51_P370099

A_55_P2007470

A_55_P2125588

GE42543

GO:0001525

GO:0001942

GO:0002053

GO:0005161

GO:0005518

GO:0005576

GO:0005615

GO:0005902

GO:0007165

GO:0008083

GO:0008283

GO:0008284

GO:0009611

GO:0009887

GO:0009986

GO:0010512

GO:0010544

GO:0014910

GO:0016020

GO:0030031

GO:0030036

GO:0030335

GO:0031954

GO:0035790

GO:0035793

GO:0042803

GO:0043410

GO:0043588

GO:0046982

GO:0048008

GO:0048018

GO:0048146

GO:0048286

GO:0048407

GO:0048565

GO:0048856

GO:0050919

GO:0051781

GO:0051897

GO:0060348

GO:0060683

GO:0070374

GO:0098772

GO:1990265

GO:1990270

GO:1990401

ILMN_1256938

ILMN_2424721

M29464_s_at

mMC003552

mMR030523

Participates

as a component of

PDGF A/B heterodimer [extracellular region] (Mus musculus)

Other forms of this molecule

Pdgfa [platelet alpha granule lumen]

Pdgfa [endoplasmic reticulum lumen]

Pdgfa [Golgi lumen]

Pdgfa [Golgi membrane]

Pdgfa [extracellular region]

Inferred From

PDGFA-2 [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001350200.1, XP_011239273.1, NP_032834.1, NP_001409065.1, NP_001409068.1, XP_036020763.1, NP_001409069.1

ENSEMBL

ENSMUST00000110897, ENSMUSP00000038870, ENSMUST00000046901, ENSMUST00000076095, ENSMUSP00000106521, ENSMUSP00000075463, ENSMUSG00000025856, ENSMUSP00000106522, ENSMUST00000110896

PRO

P20033

GlyGen

P20033

MGI

97527

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