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Active platelet-derived growth factor A chain isoforms [extracellular region]
Stable Identifier
R-HSA-381940
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Autophosphorylation of PDGF alpha receptors (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Downstream signal transduction (Homo sapiens)
Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Activation of Src (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Crk binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
GRB2:SOS1 complex binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Grb7 binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Nck binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PI3-kinase binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PLC-gamma binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Phosphorylation of PLCgamma by PDGFR (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
SH2 domain of Src binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
SHP2 binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
STAT binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF dimer binds two receptors simultaneously (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF:PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGF-AA clevage by Furin (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFRs bind type I TKI (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Participants
members
PDGFA-1 [extracellular region]
(Homo sapiens)
PDGFA-2 [extracellular region]
(Homo sapiens)
Participates
as a component of
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Inferred To
Pdgfa [extracellular region]
(Mus musculus)
Pdgfa [extracellular region]
(Rattus norvegicus)
Pvf1 [extracellular region]
(Drosophila melanogaster)
PDGFA [extracellular region]
(Bos taurus)
PDGFA [extracellular region]
(Canis familiaris)
PDGFA [extracellular region]
(Sus scrofa)
pdgfab [extracellular region]
(Danio rerio)
PDGF-A (L) [extracellular region]
(Gallus gallus)
pvf-1 [extracellular region]
(Caenorhabditis elegans)
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