Reactome | CP110 and CEP97 dissociate from the centriole

CP110 and CEP97 dissociate from the centriole

Stable Identifier

R-HSA-5626227

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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CP110 and CEP97 dissociate from the centriole

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CCP110 is a negative regulator of ciliogenesis that caps the mother centriole. CCP110 may inhibit ciliogenesis in part by preventing the CEP290-dependent recruitment of RAB8A to the centrosome and cilia (Spektor et al, 2007; Tsang et al, 2008; reviewed in Tsang and Dynlacht, 2013). CCP110 and CEP97 also form a complex with the KIF24, a kinesin with centriolar microtubule depolymerizing activity that is required for the initial recruitment and/or stability of CCP110 at the centriole (Kobayashi et al, 2011). Recruitment of TTBK2 promotes the displacement of CCP110 and its binding partner CEP97. This results in the formation of a basal body and promotes recruitment of IFT complex members and allows axonemal extension to occur (Goetz et al, 2012; Ye et al, 2014; reviewed in Tsang and Dynlacht, 2013). Although the kinase activity of TTBK2 is required for cilium formation and TTBK2 has been shown to phosphorylate CEP164, the relevant physiological target during ciliogenesis has not been unambiguously identified (Cajanek et al, 2014). Similarly, the kinase activity of MARK4 is also required for ciliogenesis, and the interaction between MARK4 and ODF2, a putative substrate, is needed to promote the dissociation of the CCP110 and CEP97 proteins from the centriole (Kuhns et al, 2013; reviewed in Kim and Dynlacht, 2013).

Literature References

PubMed ID	Title	Journal	Year
24053599	CP110 and its network of partners coordinately regulate cilia assembly Tsang, WY, Dynlacht, BD	Cilia	2013
24982133	Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole Cajánek, L, Nigg, EA	Proc. Natl. Acad. Sci. U.S.A.	2014
24469809	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals Ye, X, Zeng, H, Ning, G, Reiter, JF, Liu, A	Proc. Natl. Acad. Sci. U.S.A.	2014
21620453	Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis Kobayashi, T, Tsang, WY, Li, J, Lane, W, Dynlacht, BD	Cell	2011
18694559	CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease Tsang, WY, Bossard, C, Khanna, H, Peränen, J, Swaroop, A, Malhotra, V, Dynlacht, BD	Dev. Cell	2008
23747070	Assembling a primary cilium Kim, S, Dynlacht, BD	Curr. Opin. Cell Biol.	2013
23400999	The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis Kuhns, S, Schmidt, KN, Reymann, J, Gilbert, DF, Neuner, A, Hub, B, Carvalho, R, Wiedemann, P, Zentgraf, H, Erfle, H, Klingmüller, U, Boutros, M, Pereira, G	J. Cell Biol.	2013
17719545	Cep97 and CP110 suppress a cilia assembly program Spektor, A, Tsang, WY, Khoo, D, Dynlacht, BD	Cell	2007
23141541	The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis Goetz, SC, Liem, KF, Anderson, KV	Cell	2012