CP110 and CEP97 dissociate from the centriole

Stable Identifier
R-HSA-5626227
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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CCP110 is a negative regulator of ciliogenesis that caps the mother centriole. CCP110 may inhibit ciliogenesis in part by preventing the CEP290-dependent recruitment of RAB8A to the centrosome and cilia (Spektor et al, 2007; Tsang et al, 2008; reviewed in Tsang and Dynlacht, 2013). CCP110 and CEP97 also form a complex with the KIF24, a kinesin with centriolar microtubule depolymerizing activity that is required for the initial recruitment and/or stability of CCP110 at the centriole (Kobayashi et al, 2011). Recruitment of TTBK2 promotes the displacement of CCP110 and its binding partner CEP97. This results in the formation of a basal body and promotes recruitment of IFT complex members and allows axonemal extension to occur (Goetz et al, 2012; Ye et al, 2014; reviewed in Tsang and Dynlacht, 2013). Although the kinase activity of TTBK2 is required for cilium formation and TTBK2 has been shown to phosphorylate CEP164, the relevant physiological target during ciliogenesis has not been unambiguously identified (Cajanek et al, 2014). Similarly, the kinase activity of MARK4 is also required for ciliogenesis, and the interaction between MARK4 and ODF2, a putative substrate, is needed to promote the dissociation of the CCP110 and CEP97 proteins from the centriole (Kuhns et al, 2013; reviewed in Kim and Dynlacht, 2013).

Literature References
PubMed ID Title Journal Year
24982133 Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole

Cajánek, L, Nigg, EA

Proc. Natl. Acad. Sci. U.S.A. 2014
24053599 CP110 and its network of partners coordinately regulate cilia assembly

Tsang, WY, Dynlacht, BD

Cilia 2013
24469809 C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

Ye, X, Zeng, H, Ning, G, Reiter, JF, Liu, A

Proc. Natl. Acad. Sci. U.S.A. 2014
21620453 Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis

Kobayashi, T, Tsang, WY, Li, J, Lane, W, Dynlacht, BD

Cell 2011
18694559 CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease

Tsang, WY, Bossard, C, Khanna, H, Peränen, J, Swaroop, A, Malhotra, V, Dynlacht, BD

Dev. Cell 2008
23747070 Assembling a primary cilium

Kim, S, Dynlacht, BD

Curr. Opin. Cell Biol. 2013
23400999 The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

Kuhns, S, Schmidt, KN, Reymann, J, Gilbert, DF, Neuner, A, Hub, B, Carvalho, R, Wiedemann, P, Zentgraf, H, Erfle, H, Klingmüller, U, Boutros, M, Pereira, G

J. Cell Biol. 2013
17719545 Cep97 and CP110 suppress a cilia assembly program

Spektor, A, Tsang, WY, Khoo, D, Dynlacht, BD

Cell 2007
23141541 The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Goetz, SC, Liem, KF, Anderson, KV

Cell 2012
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