Reactome | p-PROC [endoplasmic reticulum lumen]

p-PROC [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957067

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

PROC, Vitamin K-dependent protein C ecNumber3.4.21.69/ecNumber, PROC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04070 PROC

Gene Names

PROC

Chain

signal peptide:1-18, propeptide:19-42, chain:43-461, chain:43-197, chain:200-461, peptide:200-211

Reference Genes

BioGPS Gene:5624 PROC

COSMIC (genes):PROC PROC

CTD Gene:5624 PROC

dbSNP Gene:5624 PROC

ENSEMBL:ENSG00000115718 PROC

HGNC:9451 PROC

KEGG:hsa:5624 PROC

Monarch:5624 PROC

NCBI Gene:5624 PROC

OMIM:612283 PROC

UCSC:P04070 PROC

Reference Transcript

RefSeq:NM_000312.3 PROC

Other Identifiers

11743844_a_at

11745349_a_at

16885324

206259_PM_at

206259_at

2504596

2504598

2504602

2504604

2504605

2504606

2504607

2504608

2504609

2504610

2504611

2504612

2504613

39255_at

5624

8045018

A_23_P40096

A_33_P3379922

GE59643

GO:0003824

GO:0004175

GO:0004252

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0006508

GO:0007596

GO:0008236

GO:0016787

GO:0030195

GO:0043066

GO:0043226

GO:0050728

GO:0050819

GO:0140096

GO:1903142

HMNXSV003015868

ILMN_1687721

PH_hs_0000316

TC02000783.hg

X02750_at

g4506114_3p_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

8xCbxE-3D-PROC(43-197) [extracellular region]

PROC(212-461) [extracellular region]

PROC [endoplasmic reticulum lumen]

PROC(200-461) [extracellular region]

PROC(200-211) [extracellular region]

8xCbxE-3D-PROC(33-197) [endoplasmic reticulum lumen]

PROC(200-461) [endoplasmic reticulum lumen]

8xCbxE-3D-PROC(33-197) [Golgi lumen]

PROC(200-461) [Golgi lumen]

3D-PROC(33-197) [endoplasmic reticulum lumen]

PROC(33-42) [Golgi lumen]

8xCbxE-3D-PROC(43-197) [Golgi lumen]

Inferred To

phospho-p-PROC [endoplasmic reticulum lumen] (Gallus gallus)

phospho-PROC [endoplasmic reticulum lumen] (Bos taurus)

phospho-PROC [endoplasmic reticulum lumen] (Canis familiaris)

phospho-PROC [endoplasmic reticulum lumen] (Sus scrofa)

phospho-proc [endoplasmic reticulum lumen] (Xenopus tropicalis)

phospho-Proc [endoplasmic reticulum lumen] (Mus musculus)

phospho-Proc [endoplasmic reticulum lumen] (Rattus norvegicus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

Guide to Pharmacology - Targets

2396

OpenTargets

ENSG00000115718

ENSEMBL

ENSP00000234071, ENST00000234071, ENSG00000115718

ZINC - Substances

PROC_HUMAN

ZINC target

P04070

PRO

P04070

GlyGen

P04070

PDB

1AUT, 3JTC, 3F6U, 8JRV, 1LQV, 6M3C, 6M3B, 4DT7, 8JRU

HPA

ENSG00000115718-PROC

GeneCards

PROC

Pharos - Targets

P04070

Orphanet

PROC

ZINC - Predictions - Purchasable

PROC_HUMAN

HMDB Protein

HMDBP02002

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9HBH1 DEFM			0.527	2
UniProt:Q8NG41 NPB	2	NPB(25-48) [extracellular region] (R-HSA-374794) NPB(25-53) [extracellular region] (R-HSA-374790)	0.527	2
UniProt:Q9UF33 EPHA6	2	EPHA6 [plasma membrane] (R-HSA-2682332) p-Y606,Y612-EPHA6 [plasma membrane] (R-HSA-3928368)	0.527	2