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PROC(212-461)
Stable Identifier
R-HSA-141048
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
activated protein C heavy chain
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Activated protein C binds Protein S (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C cleaves factor VIIIa (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C is released from PROCR (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated protein C:PROCR binds F2R (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
PROCR:Activated protein C:F2R [plasma membrane] (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
PROCR binds Protein C (Homo sapiens)
PROCR(18-?):Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
SERPINA5 binds activated protein C (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Soluble PROCR binds activated protein C (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
PROCR(18-?):Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
factor V -> factor Va + factor V activation peptide (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
PROC(212-461) [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
6589623
Characterization of a cDNA coding for human protein C
Proc Natl Acad Sci U S A
1984
2405901
Endoproteolytic processing of the dibasic cleavage site in the human protein C precursor in transfected mammalian cells: effects of sequence alterations on efficiency of cleavage
Biochemistry
1990
468991
Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin
J Clin Invest
1979
External Reference Information
External Reference
UniProt:P04070 PROC
Gene Names
PROC
Chain
signal peptide:1-18, propeptide:19-42, chain:43-461, chain:43-197, chain:200-461, peptide:200-211
Reference Genes
BioGPS Gene:5624 PROC
COSMIC (genes):PROC PROC
CTD Gene:5624 PROC
dbSNP Gene:5624 PROC
ENSEMBL:ENSG00000115718 PROC
HGNC:9451 PROC
KEGG Gene (Homo sapiens):hsa:5624 PROC
Monarch:5624 PROC
NCBI Gene:5624 PROC
OMIM:612283 PROC
UCSC:P04070 PROC
Reference Transcript
RefSeq:NM_000312.3 PROC
Other Identifiers
0002760408
11743844_a_at
11745349_a_at
16721
16792
16885324
1AUT
1LQV
1PCU
206259_at
2PCT
39255_at
3F6U
3JTC
4DT7
5550
5624
8045018
A_23_P40096
A_33_P3379922
AAA60164
AAA60165
AAA60166
AAB26335
AAH34377
AAK56377
AAY15044
AC068282
AF378903
AK298454
BAG60669
BC034377
CAA26528
CAB016721
CAB016792
CCDS2145
CH471103
EAW95320
ENSG00000115718
ENSP00000234071
ENST00000234071
EntrezGene:5624
g4506114_3p_at
GE59643
GO:0001889
GO:0004252
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0006465
GO:0006508
GO:0006888
GO:0007596
GO:0007599
GO:0008233
GO:0008236
GO:0016787
GO:0017187
GO:0030195
GO:0043066
GO:0043687
GO:0044267
GO:0044537
GO:0050728
GO:0050819
GO:0050900
GO:1903142
HGNC:9451
HPA005550
Hs.224698
ILMN_1687721
ILMN_1714316
IPR000152
IPR000294
IPR000742
IPR001254
IPR001314
IPR001881
IPR009003
IPR013032
IPR017857
IPR018097
IPR018114
IPR033116
K02059
LRG_599
LRG_599t1
M11228
M12683
M12684
M12685
M12686
M12687
M12712
MIM:176860
MIM:612283
MIM:612304
NM_000312
NP_000303
PF00008
PF00089
PF00594
PF14670
PH_hs_0000316
PR00001
PR00722
PROC
PROC-201
S58668
S76088
S76090
SM00020
SM00069
SM00179
SM00181
TC02000783.hg
uc002tok.4
UPI0000001646
X02750
X02750_at
XM_005263717
XM_017004505
XP_005263774
XP_016859994
Participant Of
hasComponent
Activated protein C [extracellular region]
Other forms of this molecule
8xCbxE-3D-PROC(43-197) [Golgi lumen]
PROC(33-42) [Golgi lumen]
PROC(200-461) [Golgi lumen]
8xCbxE-3D-PROC(33-197) [Golgi lumen]
8xCbxE-3D-PROC(33-197) [endoplasmic reticulum lumen]
3D-PROC(33-197) [endoplasmic reticulum lumen]
PROC(200-461) [endoplasmic reticulum lumen]
PROC(200-211) [extracellular region]
PROC [endoplasmic reticulum lumen]
p-PROC [endoplasmic reticulum lumen]
PROC(200-461) [extracellular region]
8xCbxE-3D-PROC(43-197) [extracellular region]
Inferred To
Homologues of PROC(212-461) [extracellular region] (Danio rerio)
PROC(212-461) [extracellular region] (Bos taurus)
PROC(212-461) [extracellular region] (Canis familiaris)
PROC(212-461) [extracellular region] (Danio rerio)
PROC(212-461) [extracellular region] (Gallus gallus)
PROC(212-461) [extracellular region] (Mus musculus)
PROC(212-461) [extracellular region] (Rattus norvegicus)
PROC(212-461) [extracellular region] (Sus scrofa)
PROC(212-461) [extracellular region] (Taeniopygia guttata)
PROC(212-461) [extracellular region] (Xenopus tropicalis)
Cross References
RefSeq
NP_000303.1
Brenda
3.4.21.69
GeneCards
P04070
ZINC - Substances
PROC_HUMAN
DOCK Blaster
3F6U
,
3JTC
,
4DT7
,
1AUT
,
1LQV
ZINC target
P04070
PRO
P04070
ZINC - Predictions - Purchasable
PROC_HUMAN
Orphanet
15143
HMDB Protein
HMDBP02002
PDB
1PCU
,
3F6U
,
4DT7
,
1LQV
,
2PCT
,
1AUT
,
3JTC
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A8MQ03 CRTP1
0.488
4
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