PROC(212-461) [extracellular region]

Stable Identifier
R-HSA-141048
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
activated protein C heavy chain
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
6589623 Characterization of a cDNA coding for human protein C

Foster, DC, Davie, EW

Proc Natl Acad Sci U S A 1984
2405901 Endoproteolytic processing of the dibasic cleavage site in the human protein C precursor in transfected mammalian cells: effects of sequence alterations on efficiency of cleavage

Foster, DC, Sprecher, CA, Holly, RD, Gambee, JE, Walker, KM, Kumar, AA

Biochemistry 1990
468991 Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin

Kisiel, W

J Clin Invest 1979
External Reference Information
External Reference
UniProt:P04070 PROC
Gene Names
PROC
Chain
signal peptide:1-18, propeptide:19-42, chain:43-461, chain:43-197, chain:200-461, peptide:200-211
Reference Genes
BioGPS Gene:5624 PROC
COSMIC (genes):PROC PROC
CTD Gene:5624 PROC
dbSNP Gene:5624 PROC
ENSEMBL:ENSG00000115718 PROC
HGNC:9451 PROC
KEGG Gene (Homo sapiens):5624 PROC
Monarch:5624 PROC
NCBI Gene:5624 PROC
OMIM:612283 PROC
UCSC:P04070 PROC
Reference Transcript
Other Identifiers
0002760408
11743844_a_at
11745349_a_at
16721
16792
16885324
1AUT
1LQV
1PCU
206259_at
2504596
2504598
2504602
2504604
2504605
2504606
2504607
2504608
2504609
2504610
2504611
2504612
2504613
2PCT
39255_at
3F6U
3JTC
4DT7
5550
5624
8045018
A_23_P40096
A_33_P3379922
AAA60164
AAA60165
AAA60166
AAB26335
AAH34377
AAK56377
AAY15044
AC068282
AF378903
AK298454
BAG60669
BC034377
CAA26528
CAB016721
CAB016792
CCDS2145
CH471103
E7END6
E7ENR9
E7EU72
E7EVH6
EAW95320
ENSG00000115718
ENSP00000234071
ENST00000234071
ENST00000234071.7
EntrezGene:5624
EntrezGene:PROC
F2Z2A0
g4506114_3p_at
GE59643
GO:0003674
GO:0004252
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0006464
GO:0006508
GO:0006810
GO:0006888
GO:0006950
GO:0007596
GO:0007599
GO:0008150
GO:0008219
GO:0008233
GO:0008236
GO:0016192
GO:0016787
GO:0030154
GO:0030195
GO:0043066
GO:0043167
GO:0043226
GO:0043687
GO:0044267
GO:0048856
GO:0050728
GO:0050819
GO:1903142
HGNC:9451
HPA005550
ILMN_1687721
ILMN_1714316
IPR000152
IPR000294
IPR000742
IPR001254
IPR001314
IPR001881
IPR009003
IPR012224
IPR013032
IPR017857
IPR018097
IPR018114
IPR033116
IPR035972
K02059
LRG_599
LRG_599t1
M11228
M12683
M12684
M12685
M12686
M12687
M12712
MIM:176860
MIM:612283
MIM:612304
NM_000312
NP_000303
PF00008
PF00089
PF00594
PF14670
PH_hs_0000316
PR00001
PR00722
PROC
PROC-201
S58668
S76088
S76090
SM00020
SM00069
SM00179
SM00181
TC02000783.hg
UPI0000001646
X02750
X02750_at
XM_005263717
XM_017004505
XM_024453004
XP_005263774
XP_016859994
XP_024308772
Participant Of
hasComponent
Other forms of this molecule
8xCbxE-3D-PROC(43-197) [Golgi lumen]
PROC(33-42) [Golgi lumen]
PROC(200-461) [Golgi lumen]
8xCbxE-3D-PROC(33-197) [Golgi lumen]
8xCbxE-3D-PROC(33-197) [endoplasmic reticulum lumen]
3D-PROC(33-197) [endoplasmic reticulum lumen]
PROC(200-461) [endoplasmic reticulum lumen]
PROC(200-211) [extracellular region]
PROC [endoplasmic reticulum lumen]
p-PROC [endoplasmic reticulum lumen]
PROC(200-461) [extracellular region]
8xCbxE-3D-PROC(43-197) [extracellular region]
Inferred To
Dmel\CG33458 [extracellular region] (Drosophila melanogaster)
proc [extracellular region] (Xenopus tropicalis)
SPH161 [extracellular region] (Drosophila melanogaster)
Homologues of PROC(212-461) [extracellular region] (Drosophila melanogaster)
HDC06756 [extracellular region] (Drosophila melanogaster)
Ghost homologue of PROC(212-461) [extracellular region] (Danio rerio)
PROC [extracellular region] (Canis familiaris)
PROC [extracellular region] (Gallus gallus)
Proc [extracellular region] (Mus musculus)
Proc [extracellular region] (Rattus norvegicus)
Cross References
RefSeq
OpenTargets
GeneCards
ZINC - Substances
HPA
ZINC target
Ensembl
PRO
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
PDB
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:A8MQ03 CRTP1      0.556 3
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